Shubh D. Sharma

Cyclic lactam .alpha.-melanotropin analogs of Ac-Nle4-cyclo[Asp5,D-Phe7,Lys10]-.alpha.-melanocyte-stimulating hormone-(4-10)-NH2 with bulky aromatic amino acids at position 7 show high antagonist potency and selectivity at specific melanocortin receptors

Victor J. Hrubu, Dongsi Lu, Shubh D. Sharma et al. · Journal of Medicinal Chemistry · 1995 · 352 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +12

MC4R agonism promotes durable weight loss in patients with leptin receptor deficiency

Karine Clément, Heike Biebermann, I. Sadaf Farooqi et al. · Nature Medicine · 2018 · 310 citations

Life Sciences, Endocrinology, Genetics +12

Evaluation of a melanocortin-4 receptor (MC4R) agonist (Setmelanotide) in MC4R deficiency

Tinh‐Hai Collet, B. Dubern, Jacek Mokrosiński et al. · Molecular Metabolism · 2017 · 300 citations · Full text

Life Sciences, Pharmacology, Physiology +16

Melanocortin Antagonists Define Two Distinct Pathways of Cardiovascular Control by α- and γ-Melanocyte-Stimulating Hormones

Si-Jia Li, K Varga, P. G. Archer et al. · Journal of Neuroscience · 1996 · 153 citations · Full text

Medicine, Neuroscience, Pharmacology +16

Selectivity of Cyclic [d-Nal7] and [d-Phe7] Substituted MSH Analogues for the Melanocortin Receptor Subtypes

Helgi B. Schiöth, Ruta Muceniece, Felikss Mutulis et al. · Peptides · 1997 · 87 citations

Medicine, Medicinal Chemistry, Pharmacology +9