Yongqin Wan

Synthesis, Structure–Activity Relationships, and in Vivo Efficacy of the Novel Potent and Selective Anaplastic Lymphoma Kinase (ALK) Inhibitor 5-Chloro-<i>N</i>2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-<i>N</i>4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine (LDK378) Currently in Phase 1 and Phase 2 Clinical Trials

Thomas H. Marsilje, Wei Pei, Bei Chen et al. · Journal of Medicinal Chemistry · 2013 · 412 citations · Full text

Pharmacy, Medicinal Chemistry, Oncology +16

Identification of NVP-TAE684, a potent, selective, and efficacious inhibitor of NPM-ALK

Anna Galkin, Jonathan S. Melnick, Sung Joon Kim et al. · Proceedings of the National Academy of Sciences · 2006 · 377 citations · Full text

Life Sciences, Oncology, Pharmacology +17

Roscovitine Targets, Protein Kinases and Pyridoxal Kinase

Stéphane Bach, Marie Knockaert, Jens Reinhardt et al. · Journal of Biological Chemistry · 2005 · 349 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +14

Discovery of NVP-LDE225, a Potent and Selective Smoothened Antagonist

Shifeng Pan, Xu Wu, Jiqing Jiang et al. · ACS Medicinal Chemistry Letters · 2010 · 328 citations

Pharmacy, Medicinal Chemistry, Pharmacology +15

Synthesis and Target Identification of Hymenialdisine Analogs

Yongqin Wan, Wooyoung Hur, Charles Y. Cho et al. · Chemistry & Biology · 2004 · 136 citations · Full text

Pharmacy, Chemistry, Medicinal Chemistry +11