<i>N</i>-(Cycloalkylamino)acyl-2-aminothiazole Inhibitors of Cyclin-Dependent Kinase 2. <i>N</i>-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4- piperidinecarboxamide (BMS-387032), a Highly Efficacious and Selective Antitumor Agent

Raj N. Misra, Hai‐Yun Xiao, Kyoung S. Kim, +23

Journal of Medicinal Chemistry

Chemoprevention StrategyImmunologyPharmacotherapyCdk2/cyce IcPharmaceutical Chemistry +17

Discovery of the Pyrrolo[2,1-<i>f</i>][1,2,4]triazine Nucleus as a New Kinase Inhibitor Template

John T. Hunt, Toomas Mitt, R. M. Borzilleri, +11

Journal of Medicinal Chemistry

Molecular PharmacologyMedicinal ChemistryQuinazoline-based Kinase InhibitorsBiochemistryNatural Sciences +12

Discovery of Clinical Candidate BMS-906024: A Potent Pan-Notch Inhibitor for the Treatment of Leukemia and Solid Tumors

Ashvinikumar V. Gavai, Claude Quesnelle, Derek Norris, +35

ACS Medicinal Chemistry Letters

Solid TumorsPharmacotherapyTumor BiologyMyeloid NeoplasiaHematological Malignancy +16

Identification of a novel series of tetrahydrodibenzazocines as inhibitors of 17β-hydroxysteroid dehydrogenase type 3

Brian E. Fink, Ashvinikumar V. Gavai, John S. Tokarski, +11

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryAldehyde DehydrogenaseNovel SeriesBiochemistryNatural Sciences +5

Discovery and Preclinical Pharmacology of an Oral Bromodomain and Extra-Terminal (BET) Inhibitor Using Scaffold-Hopping and Structure-Guided Drug Design

Ashvinikumar V. Gavai, Derek Norris, George V. Delucca, +42

Journal of Medicinal Chemistry

New C-5 substituted pyrrolotriazine dual inhibitors of EGFR and HER2 protein tyrosine kinases

Harold Mastalerz, Ming Chang, Ping Chen, +20

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryBiochemistryMedicineNatural SciencesNew C-5 +10

A potent, tissue-selective, synthetic inhibitor of HMG-CoA reductase

Niranjan Balasubramanian, Peter J. Brown, John D. Catt, +4

Journal of Medicinal Chemistry

Molecular PharmacologyMedicinal ChemistryPharmaceutical ScienceAldo-keto ReductaseBiochemistry +11

Discovery and Preclinical Evaluation of [4-[[1-(3-fluorophenyl)methyl]-1<i>H</i>-indazol-5-ylamino]-5-methylpyrrolo[2,1-<i>f</i>][1,2,4]triazin-6-yl]carbamic Acid, (3<i>S</i>)-3-Morpholinylmethyl Ester (BMS-599626), a Selective and Orally Efficacious Inhibitor of Human Epidermal Growth Factor Receptor 1 and 2 Kinases

Ashvinikumar V. Gavai, Brian E. Fink, David J. Fairfax, +22

Journal of Medicinal Chemistry

Orally Efficacious InhibitorKinase InhibitorsPharmacotherapyDermatologyPharmaceutical Chemistry +17

5-((4-Aminopiperidin-1-yl)methyl)pyrrolotriazine dual inhibitors of EGFR and HER2 protein tyrosine kinases

Harold Mastalerz, Ming Chang, Ping Chen, +19

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryBiochemistryMedicineNatural SciencesReceptor Tyrosine Kinase +8

General approach for the synthesis of polyquinenes via the Weiss reaction XV. Synthesis of the [5.5.5.5]fenestrane system via the aldol approach and studies directed toward the [5.5.6.6]fenestranes

Xiaoyong Fu, G. KUBIAK, Weijiang Zhang, +3

Tetrahedron

Aldol ApproachWeiss Reaction XvGeneral ApproachOrganic ChemistryChemistry +4