Randall K. Johnson

Synthesis of water-soluble (aminoalkyl)camptothecin analogs: inhibition of topoisomerase I and antitumor activity

William D. Kingsbury, Jeffrey C. Boehm, Dalia R. Jakas et al. · Journal of Medicinal Chemistry · 1991 · 516 citations

Pharmaceutical Science, Antitumor Activity, Altmetric Attention Score +16

Proliferation- and cell cycle-dependent differences in expression of the 170 kilodalton and 180 kilodalton forms of topoisomerase II in NIH-3T3 cells.

Richard Woessner, Michael R. Mattern, Christopher K. Mirabelli et al. · PubMed · 1991 · 462 citations

Chromatin, Cell Division, Biochemistry +12

Active efflux of daunorubicin and adriamycin in sensitive and resistant sublines of P388 leukemia.

Makoto Inaba, Harumi Kobayashi, Yoshio Sakurai et al. · PubMed · 1979 · 453 citations

Pathology, Pharmacotherapy, Antimicrobial Chemotherapy +19

Mammalian Chk2 is a downstream effector of the ATM-dependent DNA damage checkpoint pathway

Priya Chaturvedi, Wai K Eng, Yuan Zhu et al. · Oncogene · 1999 · 423 citations

Chromatin, Genome Instability, Cell Regulation +8

Modification of the hydroxylactone ring of camptothecin: inhibition of mammalian topoisomerase I and biological activity

Robert Hertzberg, Mary Jo Caranfa, Kenneth G. Holden et al. · Journal of Medicinal Chemistry · 1989 · 411 citations