Brajesh Kumar

Targeting the AAA ATPase p97 as an Approach to Treat Cancer through Disruption of Protein Homeostasis

Daniel J. Anderson, Ronan Le Moigne, Stevan Djakovic et al. · Cancer Cell · 2015 · 392 citations · Full text

Protein Function, Medicine, Natural Sciences +13

Discovery of a First-in-Class, Potent, Selective, and Orally Bioavailable Inhibitor of the p97 AAA ATPase (CB-5083)

Han-Jie Zhou, Jinhai Wang, Bing Yao et al. · Journal of Medicinal Chemistry · 2015 · 184 citations · Full text

Apoptosis, Cell Death, Protein Homeostasis +20

Differential Roles of the COOH Termini of AAA Subunits of PA700 (19 S Regulator) in Asymmetric Assembly and Activation of the 26 S Proteasome

Thomas G. Gillette, Brajesh Kumar, David C. Thompson et al. · Journal of Biological Chemistry · 2008 · 150 citations · Full text

Protein Assembly, Proteasome, Molecular Biology +16

Molecular and Cellular Roles of PI31 (PSMF1) Protein in Regulation of Proteasome Function

Xiaohua Li, David C. Thompson, Brajesh Kumar et al. · Journal of Biological Chemistry · 2014 · 73 citations · Full text

E1-E2 Interactions in Ubiquitin and Nedd8 Ligation Pathways

Zeynep Tokgöz, Thomas J. Siepmann, Frederick C. Streich et al. · Journal of Biological Chemistry · 2011 · 56 citations · Full text