Han-Jie Zhou

Targeting the AAA ATPase p97 as an Approach to Treat Cancer through Disruption of Protein Homeostasis

Daniel J. Anderson, Ronan Le Moigne, Stevan Djakovic et al. · Cancer Cell · 2015 · 392 citations · Full text

Protein Function, Medicine, Natural Sciences +13

Design and Synthesis of an Orally Bioavailable and Selective Peptide Epoxyketone Proteasome Inhibitor (PR-047)

Han-Jie Zhou, Monette Aujay, Mark K. Bennett et al. · Journal of Medicinal Chemistry · 2009 · 271 citations · Full text

Discovery of a First-in-Class, Potent, Selective, and Orally Bioavailable Inhibitor of the p97 AAA ATPase (CB-5083)

Han-Jie Zhou, Jinhai Wang, Bing Yao et al. · Journal of Medicinal Chemistry · 2015 · 184 citations · Full text

Apoptosis, Cell Death, Protein Homeostasis +20

Crystal structure of the proteasomal deubiquitylation module Rpn8-Rpn11

G.R. Pathare, István Nagy, P. Sledz et al. · Proceedings of the National Academy of Sciences · 2014 · 135 citations · Full text

CB-6644 Is a Selective Inhibitor of the RUVBL1/2 Complex with Anticancer Activity

Victoria A. Assimon, Yangzhong Tang, Jesse D. Vargas et al. · ACS Chemical Biology · 2019 · 91 citations

Cancer Biology, Tumor Biology, Molecular Pharmacology +17