Lihua Yu

Driver Fusions and Their Implications in the Development and Treatment of Human Cancers

Qingsong Gao, Wen-Wei Liang, Steven M. Foltz et al. · Cell Reports · 2018 · 633 citations · Full text

H3B-8800, an orally available small-molecule splicing modulator, induces lethality in spliceosome-mutant cancers

Michael Seiler, Akihide Yoshimi, Rachel Darman et al. · Nature Medicine · 2018 · 491 citations · Full text

Tumor Biology, Medicine, Rna Splicing +9

Cancer-Associated SF3B1 Hotspot Mutations Induce Cryptic 3′ Splice Site Selection through Use of a Different Branch Point

Rachel Darman, Michael Seiler, Anant A. Agrawal et al. · Cell Reports · 2015 · 453 citations · Full text

Genetics, Rna Splicing, Molecular Biology +17

Physiologic Expression of Sf3b1 K700E Causes Impaired Erythropoiesis, Aberrant Splicing, and Sensitivity to Therapeutic Spliceosome Modulation

Esther A. Obeng, Ryan Chappell, Michael Seiler et al. · Cancer Cell · 2016 · 378 citations · Full text

Signaling Pathway, Aberrant Splicing, Receptor Tyrosine Kinase +7

Splicing modulators act at the branch point adenosine binding pocket defined by the PHF5A–SF3b complex

Teng Teng, Jennifer Tsai, Xiaoling Puyang et al. · Nature Communications · 2017 · 147 citations · Full text