Sahil Patel

Discovery of (2,4-Dihydroxy-5-isopropylphenyl)-[5-(4-methylpiperazin-1-ylmethyl)-1,3-dihydroisoindol-2-yl]methanone (AT13387), a Novel Inhibitor of the Molecular Chaperone Hsp90 by Fragment Based Drug Design

Andrew Woodhead, Hayley C. Angove, Maria G. Carr et al. · Journal of Medicinal Chemistry · 2010 · 263 citations

Pharmacy, Medicinal Chemistry, Pharmacology +17

Application of Fragment-Based Lead Generation to the Discovery of Novel, Cyclic Amidine β-Secretase Inhibitors with Nanomolar Potency, Cellular Activity, and High Ligand Efficiency

Philip D. Edwards, Jeffrey S. Albert, Mark Sylvester et al. · Journal of Medicinal Chemistry · 2007 · 211 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Fragment-Based Drug Discovery Applied to Hsp90. Discovery of Two Lead Series with High Ligand Efficiency

Christopher W. Murray, Maria G. Carr, Owen Callaghan et al. · Journal of Medicinal Chemistry · 2010 · 186 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Apo and Inhibitor Complex Structures of BACE (β-secretase)

Sahil Patel, Laurent Vuillard, Anne Cleasby et al. · Journal of Molecular Biology · 2004 · 180 citations

Life Sciences, Biochemistry, Molecular Biology +11

Priming agents transiently reduce the clearance of cell-free DNA to improve liquid biopsies

Carmen Martin-Alonso, Shervin Tabrizi, Kan Xiong et al. · Science · 2024 · 160 citations · Full text

Medicine, Molecular Biology, Oncology +17