AAV-mediated direct in vivo CRISPR screen identifies functional suppressors in glioblastoma

Ryan D. Chow, Christopher D. Guzman, Guangchuan Wang, +14

Nature Neuroscience

Off-target EffectGliomaGenome EngineeringGenome EditingGene Editing +6

Single-cut genome editing restores dystrophin expression in a new mouse model of muscular dystrophy

Leonela Amoasii, Chengzu Long, Hui Li, +10

Science Translational Medicine

Cas9-specific immune responses compromise local and systemic AAV CRISPR therapy in multiple dystrophic canine models

Chady H. Hakim, Sandeep Kumar, Dennis O. Pérez‐López, +21

Nature Communications

Transcriptional recording by CRISPR spacer acquisition from RNA

Florian Schmidt, Mariia Y. Cherepkova, Randall J. Platt

Nature

Transcriptional RegulationCrispr Spacer AcquisitionGeneticsGene EditingGenome Editing +4

Noninvasive assessment of gut function using transcriptional recording sentinel cells

Florian Schmidt, Jakob Zimmermann, Tanmay Tanna, +4

Science

Alterations along the Hypothalamic-Pituitary-Thyroid Axis of the Zebrafish (<i>Danio rerio</i>) after Exposure to Propylthiouracil

Florian Schmidt, Thomas Braunbeck

Journal of Thyroid Research

Xenopus LaevisNeuroendocrinologyParathyroid GlandThyroid AxisAquaculture +18

Effects of the anti-thyroidal compound potassium-perchlorate on the thyroid system of the zebrafish

Florian Schmidt, Sarah Schnurr, Raoul Wolf, +1

Aquatic Toxicology

Anti-thyroidal Compound Potassium-perchlorateMedicineIodine Deficiency DisordersPhysiologyThyroid Disease +6

Creating functional engineered variants of the single-module non-ribosomal peptide synthetase IndC by T domain exchange

Ralf Beer, Konrad Herbst, Nikolaos Ignatiadis, +18

Molecular BioSystems

Perchlorate and ethylenethiourea induce different histological and molecular alterations in a non-mammalian vertebrate model of thyroid goitrogenesis

Robert Opitz, Florian Schmidt, Thomas Braunbeck, +2

Molecular and Cellular Endocrinology

BiologyEndocrine DisruptorsEthylenethiourea InduceIodine Deficiency DisordersPhysiology +12

Ex Vivo/In vivo Gene Editing in Hepatocytes Using “All-in-One” CRISPR-Adeno-Associated Virus Vectors with a Self-Linearizing Repair Template

Simon Krooss, Zhen Dai, Florian Schmidt, +15

iScience