Christopher D. Guzman

Highly efficient Cas9-mediated transcriptional programming

Alejandro Chavez, Jonathan Scheiman, Suhani Vora et al. · Nature Methods · 2015 · 1.6K citations · Full text

Transcriptional Regulation, Natural Sciences, Molecular Biology +6

Systematic Immunotherapy Target Discovery Using Genome-Scale In Vivo CRISPR Screens in CD8 T Cells

Matthew B. Dong, Guangchuan Wang, Ryan D. Chow et al. · Cell · 2019 · 308 citations · Full text

Off-target Effect, Genome Surgery, Cd8 T Cells +11

AAV-mediated direct in vivo CRISPR screen identifies functional suppressors in glioblastoma

Ryan D. Chow, Christopher D. Guzman, Guangchuan Wang et al. · Nature Neuroscience · 2017 · 243 citations · Full text

Off-target Effect, Glioma, Genome Engineering +8

Synthetic biosensors for precise gene control and real-time monitoring of metabolites

Jameson K. Rogers, Christopher D. Guzman, Noah D. Taylor et al. · Nucleic Acids Research · 2015 · 240 citations · Full text

Real-time Monitoring, Engineering, Biomolecular Tool +25

Mapping a functional cancer genome atlas of tumor suppressors in mouse liver using AAV-CRISPR–mediated direct in vivo screening

Guangchuan Wang, Ryan D. Chow, Lupeng Ye et al. · Science Advances · 2018 · 106 citations · Full text