Brian Spencer

Inclusion formation and neuronal cell death through neuron-to-neuron transmission of α-synuclein

Paula Desplats, He-Jin Lee, Eun-Jin Bae et al. · Proceedings of the National Academy of Sciences · 2009 · 1.5K citations · Full text

Life Sciences, Neurology, Neuroscience +17

The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid β accumulation in mice

Fiona Pickford, Eliezer Masliah, Markus Britschgi et al. · Journal of Clinical Investigation · 2008 · 1.1K citations

Life Sciences, Neurobiology, Neuroscience +17

Beclin 1 Gene Transfer Activates Autophagy and Ameliorates the Neurodegenerative Pathology in α-Synuclein Models of Parkinson's and Lewy Body Diseases

Brian Spencer, Rewati Potkar, Margarita Trejo et al. · Journal of Neuroscience · 2009 · 582 citations · Full text

Life Sciences, Neurobiology, Neuroscience +17

Defective CFTR induces aggresome formation and lung inflammation in cystic fibrosis through ROS-mediated autophagy inhibition

Alessandro Luciani, Valeria Rachela Villella, Speranza Esposito et al. · Nature Cell Biology · 2010 · 460 citations

Life Sciences, Cell Biology, Molecular Genetics +17

Passive Immunization Reduces Behavioral and Neuropathological Deficits in an Alpha-Synuclein Transgenic Model of Lewy Body Disease

Eliezer Masliah, Edward Rockenstein, Michael Mante et al. · PLoS ONE · 2011 · 422 citations · Full text

Life Sciences, Neurology, Neuroscience +17