Samir Ali

The Hepatitis C Virus Replicon Presents a Higher Barrier to Resistance to Nucleoside Analogs than to Nonnucleoside Polymerase or Protease Inhibitors

Matthew F. McCown, Sonal Rajyaguru, Sophie Le Pogam et al. · Antimicrobial Agents and Chemotherapy · 2008 · 164 citations · Full text

Life Sciences, Molecular Biology, Molecular Genetics +17

Selection and Characterization of Replicon Variants Dually Resistant to Thumb- and Palm-Binding Nonnucleoside Polymerase Inhibitors of the Hepatitis C Virus

Sophie Le Pogam, Hyunsoon Kang, Seth F. Harris et al. · Journal of Virology · 2006 · 131 citations · Full text

Life Sciences, Molecular Biology, Molecular Pharmacology +16

In vitro selected Con1 subgenomic replicons resistant to 2′-C-Methyl-Cytidine or to R1479 show lack of cross resistance

Sophie Le Pogam, Wen-Rong Jiang, Vincent Lévêque et al. · Virology · 2006 · 128 citations

Life Sciences, Genetics, Molecular Biology +13

Characterization of the Metabolic Activation of Hepatitis C Virus Nucleoside Inhibitor β-d-2′-Deoxy-2′-fluoro-2′-C-methylcytidine (PSI-6130) and Identification of a Novel Active 5′-Triphosphate Species

Han Ma, Wen-Rong Jiang, Nicole L. Robledo et al. · Journal of Biological Chemistry · 2007 · 114 citations · Full text

Life Sciences, Biochemistry, Pharmacology +17

Selected Replicon Variants with Low-Level In Vitro Resistance to the Hepatitis C Virus NS5B Polymerase Inhibitor PSI-6130 Lack Cross-Resistance with R1479

Samir Ali, Vincent Lévêque, Sophie Le Pogam et al. · Antimicrobial Agents and Chemotherapy · 2008 · 106 citations · Full text

Life Sciences, Medicinal Chemistry, Molecular Biology +17