The Hepatitis C Virus Replicon Presents a Higher Barrier to Resistance to Nucleoside Analogs than to Nonnucleoside Polymerase or Protease Inhibitors

Matthew F. McCown, Sonal Rajyaguru, Sophie Le Pogam, +6

Antimicrobial Agents and Chemotherapy

Hcv RepliconHepatitis C VirusImmunologyMolecular BiologyPharmacotherapy +17

Existence of hepatitis C virus NS5B variants naturally resistant to non-nucleoside, but not to nucleoside, polymerase inhibitors among untreated patients

Sophie Le Pogam, A. Seshaadri, Alan Kosaka, +7

Journal of Antimicrobial Chemotherapy

Selection and Characterization of Replicon Variants Dually Resistant to Thumb- and Palm-Binding Nonnucleoside Polymerase Inhibitors of the Hepatitis C Virus

Sophie Le Pogam, Hyunsoon Kang, Seth F. Harris, +13

Journal of Virology

Thumb Site InhibitorBiochemistryHepatitis C VirusViral HepatitisMultiple Nonnucleoside Inhibitor +13

In vitro selected Con1 subgenomic replicons resistant to 2′-C-Methyl-Cytidine or to R1479 show lack of cross resistance

Sophie Le Pogam, Wen-Rong Jiang, Vincent Lévêque, +11

Virology

Cross ResistanceMolecular ResearchCon1 Subgenomic RepliconsNatural SciencesGenetics +8

GT-1a or GT-1b Subtype-Specific Resistance Profiles for Hepatitis C Virus Inhibitors Telaprevir and HCV-796

Matthew F. McCown, Sonal Rajyaguru, Simran Kular, +2

Antimicrobial Agents and Chemotherapy

Viral ReplicationHepatitis CViral HepatitisReplication LevelsPathogenesis +13

Application of the Phosphoramidate ProTide Approach to 4‘-Azidouridine Confers Sub-micromolar Potency versus Hepatitis C Virus on an Inactive Nucleoside

Plinio Perrone, G Luoni, Mary Rose Kelleher, +12

Journal of Medicinal Chemistry

Cell CultureAntiviral DrugHcv ReplicationChemical BiologyInactive Nucleoside +14

The Design, Synthesis, and Antiviral Activity of Monofluoro and Difluoro Analogues of 4′-Azidocytidine against Hepatitis C Virus Replication: The Discovery of 4′-Azido-2′-deoxy-2′-fluorocytidine and 4′-Azido-2′-dideoxy-2′,2′-difluorocytidine

David B. Smith, Genadiy Kalayanov, Christian Sund, +16

Journal of Medicinal Chemistry

2′-Deoxy-4′-azido Nucleoside Analogs Are Highly Potent Inhibitors of Hepatitis C Virus Replication Despite the Lack of 2′-α-Hydroxyl Groups

Klaus Klumpp, Genadiy Kalayanov, Han Ma, +21

Journal of Biological Chemistry

Slow Binding Inhibition and Mechanism of Resistance of Non-nucleoside Polymerase Inhibitors of Hepatitis C Virus

Julie Q. Hang, Yanli Yang, Seth F. Harris, +12

Journal of Biological Chemistry

First Example of Phosphoramidate Approach Applied to a 4‘-Substituted Purine Nucleoside (4‘-Azidoadenosine):  Conversion of an Inactive Nucleoside to a Submicromolar Compound versus Hepatitis C Virus

Plinio Perrone, Felice Daverio, Rocco Valente, +8

Journal of Medicinal Chemistry