Sophie Le Pogam

The Novel Nucleoside Analog R1479 (4′-Azidocytidine) Is a Potent Inhibitor of NS5B-dependent RNA Synthesis and Hepatitis C Virus Replication in Cell Culture

Klaus Klumpp, Vincent Lévêque, Sophie Le Pogam et al. · Journal of Biological Chemistry · 2005 · 215 citations · Full text

Pharmacy, Medicinal Chemistry, Molecular Biology +15

The Hepatitis C Virus Replicon Presents a Higher Barrier to Resistance to Nucleoside Analogs than to Nonnucleoside Polymerase or Protease Inhibitors

Matthew F. McCown, Sonal Rajyaguru, Sophie Le Pogam et al. · Antimicrobial Agents and Chemotherapy · 2008 · 164 citations · Full text

Life Sciences, Molecular Biology, Molecular Genetics +17

Existence of hepatitis C virus NS5B variants naturally resistant to non-nucleoside, but not to nucleoside, polymerase inhibitors among untreated patients

Sophie Le Pogam, A. Seshaadri, Alan Kosaka et al. · Journal of Antimicrobial Chemotherapy · 2008 · 134 citations

Life Sciences, Genetics, Pharmacology +17

Selection and Characterization of Replicon Variants Dually Resistant to Thumb- and Palm-Binding Nonnucleoside Polymerase Inhibitors of the Hepatitis C Virus

Sophie Le Pogam, Hyunsoon Kang, Seth F. Harris et al. · Journal of Virology · 2006 · 131 citations · Full text

Life Sciences, Molecular Biology, Molecular Pharmacology +16

In vitro selected Con1 subgenomic replicons resistant to 2′-C-Methyl-Cytidine or to R1479 show lack of cross resistance

Sophie Le Pogam, Wen-Rong Jiang, Vincent Lévêque et al. · Virology · 2006 · 128 citations

Life Sciences, Genetics, Molecular Biology +13