Sophie Le Pogam

The Novel Nucleoside Analog R1479 (4′-Azidocytidine) Is a Potent Inhibitor of NS5B-dependent RNA Synthesis and Hepatitis C Virus Replication in Cell Culture

Klaus Klumpp, Vincent Lévêque, Sophie Le Pogam et al. · Journal of Biological Chemistry · 2005 · 215 citations · Full text

The Hepatitis C Virus Replicon Presents a Higher Barrier to Resistance to Nucleoside Analogs than to Nonnucleoside Polymerase or Protease Inhibitors

Matthew F. McCown, Sonal Rajyaguru, Sophie Le Pogam et al. · Antimicrobial Agents and Chemotherapy · 2008 · 164 citations · Full text

Hcv Replicon, Hepatitis C Virus, Immunology +19

Existence of hepatitis C virus NS5B variants naturally resistant to non-nucleoside, but not to nucleoside, polymerase inhibitors among untreated patients

Sophie Le Pogam, A. Seshaadri, Alan Kosaka et al. · Journal of Antimicrobial Chemotherapy · 2008 · 134 citations

Selection and Characterization of Replicon Variants Dually Resistant to Thumb- and Palm-Binding Nonnucleoside Polymerase Inhibitors of the Hepatitis C Virus

Sophie Le Pogam, Hyunsoon Kang, Seth F. Harris et al. · Journal of Virology · 2006 · 129 citations · Full text

Thumb Site Inhibitor, Biochemistry, Hepatitis C Virus +15

In vitro selected Con1 subgenomic replicons resistant to 2′-C-Methyl-Cytidine or to R1479 show lack of cross resistance

Sophie Le Pogam, Wen-Rong Jiang, Vincent Lévêque et al. · Virology · 2006 · 128 citations

Cross Resistance, Molecular Research, Con1 Subgenomic Replicons +10