The Novel Nucleoside Analog R1479 (4′-Azidocytidine) Is a Potent Inhibitor of NS5B-dependent RNA Synthesis and Hepatitis C Virus Replication in Cell Culture

Klaus Klumpp, Vincent Lévêque, Sophie Le Pogam, +17

Journal of Biological Chemistry

The Hepatitis C Virus Replicon Presents a Higher Barrier to Resistance to Nucleoside Analogs than to Nonnucleoside Polymerase or Protease Inhibitors

Matthew F. McCown, Sonal Rajyaguru, Sophie Le Pogam, +6

Antimicrobial Agents and Chemotherapy

Hcv RepliconHepatitis C VirusImmunologyMolecular BiologyPharmacotherapy +17

Existence of hepatitis C virus NS5B variants naturally resistant to non-nucleoside, but not to nucleoside, polymerase inhibitors among untreated patients

Sophie Le Pogam, A. Seshaadri, Alan Kosaka, +7

Journal of Antimicrobial Chemotherapy

Selection and Characterization of Replicon Variants Dually Resistant to Thumb- and Palm-Binding Nonnucleoside Polymerase Inhibitors of the Hepatitis C Virus

Sophie Le Pogam, Hyunsoon Kang, Seth F. Harris, +13

Journal of Virology

Thumb Site InhibitorBiochemistryHepatitis C VirusViral HepatitisMultiple Nonnucleoside Inhibitor +13

In vitro selected Con1 subgenomic replicons resistant to 2′-C-Methyl-Cytidine or to R1479 show lack of cross resistance

Sophie Le Pogam, Wen-Rong Jiang, Vincent Lévêque, +11

Virology

Cross ResistanceMolecular ResearchCon1 Subgenomic RepliconsNatural SciencesGenetics +8

In Vivo Emergence of a Novel Mutant L159F/L320F in the NS5B Polymerase Confers Low-Level Resistance to the HCV Polymerase Inhibitors Mericitabine and Sofosbuvir

Xiao Tong, Sophie Le Pogam, Lewyn Li, +7

The Journal of Infectious Diseases

Cloning, expression, and nucleotide sequence of genes involved in production of lactococcin DR, a bacteriocin from lactococcus lactis subsp. lactis

Alain Rincé, Alain Dufour, Sophie Le Pogam, +3

Applied and Environmental Microbiology

Lactococcus Lactis SubspAntimicrobial Resistance GeneHealth SciencesLactic Acid BacteriaBacteriology +11

Selected Replicon Variants with Low-Level In Vitro Resistance to the Hepatitis C Virus NS5B Polymerase Inhibitor PSI-6130 Lack Cross-Resistance with R1479

Samir Ali, Vincent Lévêque, Sophie Le Pogam, +11

Antimicrobial Agents and Chemotherapy

Viral HepatitisImmunologyAntiviral Drug DevelopmentHepatitisMolecular Biology +12

Design, synthesis, and antiviral properties of 4′-substituted ribonucleosides as inhibitors of hepatitis C virus replication: The discovery of R1479

David B. Smith, Joseph A. Martin, Klaus Klumpp, +21

Bioorganic & Medicinal Chemistry Letters

Viral ReplicationBiochemistryNatural SciencesAntiviral Drug DevelopmentAntiviral Therapy +9

Hepatitis C in a Hemodialysis Unit: Molecular Evidence for Nosocomial Transmission

Sophie Le Pogam, D. Le Chapois, Richard Christen, +3

Journal of Clinical Microbiology

Diagnostic VirologyHemodialysisHepatologyHepatitis CHemodialysis Unit +13