The Novel Nucleoside Analog R1479 (4′-Azidocytidine) Is a Potent Inhibitor of NS5B-dependent RNA Synthesis and Hepatitis C Virus Replication in Cell Culture

Klaus Klumpp, Vincent Lévêque, Sophie Le Pogam, +17

Journal of Biological Chemistry

The Hepatitis C Virus Replicon Presents a Higher Barrier to Resistance to Nucleoside Analogs than to Nonnucleoside Polymerase or Protease Inhibitors

Matthew F. McCown, Sonal Rajyaguru, Sophie Le Pogam, +6

Antimicrobial Agents and Chemotherapy

Hcv RepliconHepatitis C VirusImmunologyMolecular BiologyPharmacotherapy +17

Existence of hepatitis C virus NS5B variants naturally resistant to non-nucleoside, but not to nucleoside, polymerase inhibitors among untreated patients

Sophie Le Pogam, A. Seshaadri, Alan Kosaka, +7

Journal of Antimicrobial Chemotherapy

Selection and Characterization of Replicon Variants Dually Resistant to Thumb- and Palm-Binding Nonnucleoside Polymerase Inhibitors of the Hepatitis C Virus

Sophie Le Pogam, Hyunsoon Kang, Seth F. Harris, +13

Journal of Virology

Thumb Site InhibitorBiochemistryHepatitis C VirusViral HepatitisMultiple Nonnucleoside Inhibitor +13

In vitro selected Con1 subgenomic replicons resistant to 2′-C-Methyl-Cytidine or to R1479 show lack of cross resistance

Sophie Le Pogam, Wen-Rong Jiang, Vincent Lévêque, +11

Virology

Cross ResistanceMolecular ResearchCon1 Subgenomic RepliconsNatural SciencesGenetics +8

Selected Replicon Variants with Low-Level In Vitro Resistance to the Hepatitis C Virus NS5B Polymerase Inhibitor PSI-6130 Lack Cross-Resistance with R1479

Samir Ali, Vincent Lévêque, Sophie Le Pogam, +11

Antimicrobial Agents and Chemotherapy

Viral HepatitisImmunologyAntiviral Drug DevelopmentHepatitisMolecular Biology +12

RG7128 Alone or in Combination with Pegylated Interferon‐α2a and Ribavirin Prevents Hepatitis C Virus (HCV) Replication and Selection of Resistant Variants in HCV‐Infected Patients

Sophie Le Pogam, A. Seshaadri, Aren Ewing, +8

The Journal of Infectious Diseases

Synthesis and Anti-HCV Activities of 4′-Fluoro-2′-Substituted Uridine Triphosphates and Nucleotide Prodrugs: Discovery of 4′-Fluoro-2′-<i>C</i>-methyluridine 5′-Phosphoramidate Prodrug (<b>AL-335</b>) for the Treatment of Hepatitis C Infection

Guangyi Wang, Natalia Dyatkina, Marija Prhavc, +18

Journal of Medicinal Chemistry

Virus-Associated Nucleases: Location and Properties of Deoxyribonucleases and Ribonucleases in Purified Frog Virus 3

Hyunsoon Kang, B.R. McAuslan

Journal of Virology

Characterization of Hepatitis C Virus (HCV) Quasispecies Dynamics upon Short-Term Dual Therapy with the HCV NS5B Nucleoside Polymerase Inhibitor Mericitabine and the NS3/4 Protease Inhibitor Danoprevir

Sophie Le Pogam, J.M. Yan, M. B. Chhabra, +9

Antimicrobial Agents and Chemotherapy

Hepatitis C VirusInform-1 StudyImmunologyPathologyAntiviral Drug +15