Preclinical Development and Clinical Translation of a PSMA-Targeted Docetaxel Nanoparticle with a Differentiated Pharmacological Profile

Jeffrey S. Hrkach, Daniel D. Von Hoff, Mir Mukkaram Ali, +26

Science Translational Medicine

Selective Killing of Mixed Lineage Leukemia Cells by a Potent Small-Molecule DOT1L Inhibitor

Scott R. Daigle, Edward J. Olhava, Carly A. Therkelsen, +18

Cancer Cell

Hematological MalignancyTumor BiologySelective KillingMedicineMixed-phenotype Acute Leukemia +6

A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells

Sarah K. Knutson, Tim J. Wigle, Natalie M. Warholic, +18

Nature Chemical Biology

Lymphoid NeoplasiaMedicineSelective InhibitorAnti-cancer AgentTumor Suppressor +6

Ectopic induction of tendon and ligament in rats by growth and differentiation factors 5, 6, and 7, members of the TGF-beta gene family.

Neil M. Wolfman, Gary Hattersley, Karen Cox, +9

Journal of Clinical Investigation

Bone RepairOrthopaedic SurgeryMusculoskeletal ResearchRegenerative MedicineSoft Tissue Injury +16

Studies with a Xenopus BMP receptor suggest that ventral mesoderm-inducing signals override dorsal signals in vivo

Jonathan M. Graff, R. Scott Thies, Jeffrey Song, +2

Cell

Neurobiological MechanismDevelopmental BiologySynaptic TransmissionPhysiologyXenopus Bmp Receptor +9

A truncated bone morphogenetic protein receptor affects dorsal-ventral patterning in the early Xenopus embryo.

Atsushi Suzuki, R. Scott Thies, Noboru Yamaji, +4

Proceedings of the National Academy of Sciences

Early Xenopus EmbryoSclerostinDevelopmental BiologyBone BiologySignal Transduction +12

Pulmonary delivery of an erythropoietin Fc fusion protein in non-human primates through an immunoglobulin transport pathway

Alan J. Bitonti, Jennifer Dumont, Susan C. Low, +12

Proceedings of the National Academy of Sciences

Small molecule activators of SIRT1 replicate signaling pathways triggered by calorie restriction in vivo

J. Joshua Smith, Renée Deehan Kenney, David Gagné, +17

BMC Systems Biology

Responsiveness of clonal limb bud cell lines to bone morphogenetic protein 2 reveals a sequential relationship between cartilage and bone cell phenotypes

Vicki Rosen, John Nove, Jeffrey Song, +3

Journal of Bone and Mineral Research

A missense mutation in SLC6A1 associated with Lennox-Gastaut syndrome impairs GABA transporter 1 protein trafficking and function

Kefu Cai, Jie Wang, Jaclyn M. Eissman, +13

Experimental Neurology

Molecular PhysiologySignal TransductionGenetic DisorderMedicineGenetics +6