James H. Thorpe

RIP1 Kinase Drives Macrophage-Mediated Adaptive Immune Tolerance in Pancreatic Cancer

Wei Wang, Jill M. Marinis, Allison M. Beal et al. · Cancer Cell · 2018 · 245 citations · Full text

Cancer Immunosurveillance, Pancreatic Cancer, Medicine +7

Major Groove Binding and ‘DNA-Induced' Fit in the Intercalation of a Derivative of the Mixed Topoisomerase I/II Poison <i>N</i>-(2-(Dimethylamino)ethyl)acridine-4- carboxamide (DACA) into DNA:  X-ray Structure Complexed to d(CG(5-BrU)ACG)₂ at 1.3-Å Resolution

Alan K. Todd, Adrienne Adams, James H. Thorpe et al. · Journal of Medicinal Chemistry · 1999 · 89 citations

Dna Analysis, Altmetric Attention Score, Molecular Biology +17

Identification of a RIP1 Kinase Inhibitor Clinical Candidate (GSK3145095) for the Treatment of Pancreatic Cancer

Philip A. Harris, Jill M. Marinis, John D. Lich et al. · ACS Medicinal Chemistry Letters · 2019 · 79 citations · Full text

Discovery and Lead-Optimization of 4,5-Dihydropyrazoles as Mono-Kinase Selective, Orally Bioavailable and Efficacious Inhibitors of Receptor Interacting Protein 1 (RIP1) Kinase

Philip A. Harris, Nicolas Faucher, Nicolas George et al. · Journal of Medicinal Chemistry · 2019 · 68 citations · Full text

Drug Target, Immunology, Efficacious Inhibitors +19

Conformational and Hydration Effects of Site-selective Sodium, Calcium and Strontium Ion Binding to the DNA Holliday Junction Structure d(TCGGTACCGA)4

James H. Thorpe, B. Gale, Susana C. M. Teixeira et al. · Journal of Molecular Biology · 2003 · 54 citations

Strontium Ion Binding, Biochemistry, Protein Folding +10