Concepedia

Zijun Chen

ZC

13

Publications

1.2K

Citations

12

H-Index

2011

Active since

Affiliations

State Key Laboratory of Genetic Engineering(Current)

Fudan University

Novartis (China)

Ministry of Natural Resources

Second Institute of Oceanography

Zijun Chen is an author at State Key Laboratory of Genetic Engineering specializing in medicine, natural sciences, and molecular biology.

Top concepts

MedicineNatural SciencesCell BiologyMolecular BiologyPhysicsEngineeringEpigeneticsCell SignalingApplied PhysicsMagnetic Resonance

Publications per year

2011–2024

13

Publications

13

Selective inhibition of Ezh2 by a small molecule inhibitor blocks tumor cells proliferation

Wei Qi, Homan Chan, Lin Teng et al. · Proceedings of the National Academy of Sciences · 2012 · 542 citations · Full text

Selective Inhibition, Tumor Biology, Methyl Group +15

An allosteric PRC2 inhibitor targeting the H3K27me3 binding pocket of EED

Wei Qi, Kehao Zhao, Justin Gu et al. · Nature Chemical Biology · 2017 · 313 citations · Full text

Signal Transduction, Signaling Pathway, Cell Regulation +7

TRIM21 regulates pyroptotic cell death by promoting Gasdermin D oligomerization

Wenqing Gao, Yuanyuan Li, Xuehe Liu et al. · Cell Death and Differentiation · 2021 · 79 citations · Full text

Transcriptional Regulation, Cell Regulation, Molecular Regulation +9

Discovery of the Clinical Candidate MAK683: An EED-Directed, Allosteric, and Selective PRC2 Inhibitor for the Treatment of Advanced Malignancies

Ying Huang, Martin Sendzik, Jeff Zhang et al. · Journal of Medicinal Chemistry · 2022 · 49 citations · Full text

Structural Basis of Human Helicase DDX21 in RNA Binding, Unwinding, and Antiviral Signal Activation

Zijun Chen, Zhengyang Li, Xiaojian Hu et al. · Advanced Science · 2020 · 44 citations · Full text

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