Zijun Chen

Selective inhibition of Ezh2 by a small molecule inhibitor blocks tumor cells proliferation

Wei Qi, Homan Chan, Lin Teng et al. · Proceedings of the National Academy of Sciences · 2012 · 542 citations · Full text

Selective Inhibition, Tumor Biology, Methyl Group +15

An allosteric PRC2 inhibitor targeting the H3K27me3 binding pocket of EED

Wei Qi, Kehao Zhao, Justin Gu et al. · Nature Chemical Biology · 2017 · 313 citations · Full text

Signal Transduction, Signaling Pathway, Cell Regulation +7

TRIM21 regulates pyroptotic cell death by promoting Gasdermin D oligomerization

Wenqing Gao, Yuanyuan Li, Xuehe Liu et al. · Cell Death and Differentiation · 2021 · 79 citations · Full text

Transcriptional Regulation, Cell Regulation, Molecular Regulation +9

Discovery of the Clinical Candidate MAK683: An EED-Directed, Allosteric, and Selective PRC2 Inhibitor for the Treatment of Advanced Malignancies

Ying Huang, Martin Sendzik, Jeff Zhang et al. · Journal of Medicinal Chemistry · 2022 · 49 citations · Full text

Structural Basis of Human Helicase DDX21 in RNA Binding, Unwinding, and Antiviral Signal Activation

Zijun Chen, Zhengyang Li, Xiaojian Hu et al. · Advanced Science · 2020 · 44 citations · Full text