Xiaojuan Xu

Dantrolene, a Therapeutic Agent for Malignant Hyperthermia, Markedly Improves the Function of Failing Cardiomyocytes by Stabilizing Interdomain Interactions Within the Ryanodine Receptor

Shigeki Kobayashi, Masafumi Yano, Takeshi Suetomi et al. · Journal of the American College of Cardiology · 2009 · 187 citations · Full text

Medicine, Cardiology, Pharmacology +17

Catecholaminergic Polymorphic Ventricular Tachycardia Is Caused by Mutation-Linked Defective Conformational Regulation of the Ryanodine Receptor

Hitoshi Uchinoumi, Masafumi Yano, Takeshi Suetomi et al. · Circulation Research · 2010 · 161 citations · Full text

Life Sciences, Cardiology, Genetics +17

Dantrolene, a Therapeutic Agent for Malignant Hyperthermia, Inhibits Catecholaminergic Polymorphic Ventricular Tachycardia in a RyR2R2474S/+ Knock-In Mouse Model

Shigeki Kobayashi, Masafumi Yano, Hitoshi Uchinoumi et al. · Circulation Journal · 2010 · 122 citations · Full text

Medicine, Cardiology, Pharmacology +17

Defective calmodulin binding to the cardiac ryanodine receptor plays a key role in CPVT-associated channel dysfunction

Xiaojuan Xu, Masafumi Yano, Hitoshi Uchinoumi et al. · Biochemical and Biophysical Research Communications · 2010 · 83 citations

Natural Sciences, Cardiology, Physiology +16

Dissociation of calmodulin from cardiac ryanodine receptor causes aberrant Ca2+ release in heart failure

Makoto Ono, Masafumi Yano, Akihiro Hino et al. · Cardiovascular Research · 2010 · 81 citations · Full text

Medicine, Cardiology, Physiology +16