Hitoshi Uchinoumi

Dantrolene, a Therapeutic Agent for Malignant Hyperthermia, Markedly Improves the Function of Failing Cardiomyocytes by Stabilizing Interdomain Interactions Within the Ryanodine Receptor

Shigeki Kobayashi, Masafumi Yano, Takeshi Suetomi et al. · Journal of the American College of Cardiology · 2009 · 187 citations · Full text

Malignant Hyperthermia, Cardiac Muscle, Cardiomyopathy +12

Catecholaminergic Polymorphic Ventricular Tachycardia Is Caused by Mutation-Linked Defective Conformational Regulation of the Ryanodine Receptor

Hitoshi Uchinoumi, Masafumi Yano, Takeshi Suetomi et al. · Circulation Research · 2010 · 160 citations · Full text

Dantrolene, a Therapeutic Agent for Malignant Hyperthermia, Inhibits Catecholaminergic Polymorphic Ventricular Tachycardia in a RyR2R2474S/+ Knock-In Mouse Model

Shigeki Kobayashi, Masafumi Yano, Hitoshi Uchinoumi et al. · Circulation Journal · 2010 · 122 citations · Full text

Oxidation of ryanodine receptor (RyR) and calmodulin enhance Ca release and pathologically alter, RyR structure and calmodulin affinity

Tetsuro Oda, Yi Yang, Hitoshi Uchinoumi et al. · Journal of Molecular and Cellular Cardiology · 2015 · 107 citations · Full text

Molecular Pharmacology, Molecular Physiology, Signal Transduction +8

CaMKII-dependent phosphorylation of RyR2 promotes targetable pathological RyR2 conformational shift

Hitoshi Uchinoumi, Yi Yang, Tetsuro Oda et al. · Journal of Molecular and Cellular Cardiology · 2016 · 106 citations · Full text

Protein Function, Molecular Physiology, Signal Transduction +9