Takeshi Suetomi

Inflammation and NLRP3 Inflammasome Activation Initiated in Response to Pressure Overload by Ca ²⁺ /Calmodulin-Dependent Protein Kinase II δ Signaling in Cardiomyocytes Are Essential for Adverse Cardiac Remodeling

Takeshi Suetomi, Andrew Willeford, Cameron S. Brand et al. · Circulation · 2018 · 289 citations · Full text

Dantrolene, a Therapeutic Agent for Malignant Hyperthermia, Markedly Improves the Function of Failing Cardiomyocytes by Stabilizing Interdomain Interactions Within the Ryanodine Receptor

Shigeki Kobayashi, Masafumi Yano, Takeshi Suetomi et al. · Journal of the American College of Cardiology · 2009 · 187 citations · Full text

Malignant Hyperthermia, Cardiac Muscle, Cardiomyopathy +12

Catecholaminergic Polymorphic Ventricular Tachycardia Is Caused by Mutation-Linked Defective Conformational Regulation of the Ryanodine Receptor

Hitoshi Uchinoumi, Masafumi Yano, Takeshi Suetomi et al. · Circulation Research · 2010 · 160 citations · Full text

Dantrolene, a Therapeutic Agent for Malignant Hyperthermia, Inhibits Catecholaminergic Polymorphic Ventricular Tachycardia in a RyR2R2474S/+ Knock-In Mouse Model

Shigeki Kobayashi, Masafumi Yano, Hitoshi Uchinoumi et al. · Circulation Journal · 2010 · 122 citations · Full text

CaMKIIδ-mediated inflammatory gene expression and inflammasome activation in cardiomyocytes initiate inflammation and induce fibrosis

Andrew Willeford, Takeshi Suetomi, Audrey Nickle et al. · JCI Insight · 2018 · 122 citations · Full text