Defective calmodulin binding to the cardiac ryanodine receptor plays a key role in CPVT-associated channel dysfunction

Xiaojuan Xu, Masafumi Yano, Hitoshi Uchinoumi, +12

Biochemical and Biophysical Research Communications

Cardiac MuscleChannelopathiesCardiomyopathyMolecular PhysiologySignal Transduction +9

Dissociation of calmodulin from cardiac ryanodine receptor causes aberrant Ca2+ release in heart failure

Makoto Ono, Masafumi Yano, Akihiro Hino, +14

Cardiovascular Research

Mutation-Linked Defective Interdomain Interactions Within Ryanodine Receptor Cause Aberrant Ca ²⁺ Release Leading to Catecholaminergic Polymorphic Ventricular Tachycardia

Takeshi Suetomi, Masafumi Yano, Hitoshi Uchinoumi, +12

Circulation

Generation of two murine monoclonal antibodies that can discriminate N-glycolyl and N-acetyl neuraminic acid residues of GM2 gangliosides.

Masayuki Miyake, Motohiko Ito, Shigeki Hitomï, +6

PubMed

ImmunologyGlycobiologyPathologyPeptide ScienceImmunotherapy +15

Enhanced binding of calmodulin to RyR2 corrects arrhythmogenic channel disorder in CPVT-associated myocytes

Masakazu Fukuda, Takeshi Yamamoto, Shigehiko Nishimura, +11

Biochemical and Biophysical Research Communications

Cardiac MuscleSignal TransductionMolecular PhysiologyEnhanced BindingCpvt-associated Myocytes +6

Enhanced binding of calmodulin to the ryanodine receptor corrects contractile dysfunction in failing hearts

Akihiro Hino, Masafumi Yano, Takayoshi Kato, +13

Cardiovascular Research

Correction of impaired calmodulin binding to RyR2 as a novel therapy for lethal arrhythmia in the pressure-overloaded heart failure

Takayoshi Kato, Takeshi Yamamoto, Yoshihide Nakamura, +18

Heart Rhythm

Cardiac MuscleCardiomyopathyHeart FailureCardiovascular DiseaseMedicine +8

90Y-Labeled Anti-ROBO1 Monoclonal Antibody Exhibits Antitumor Activity against Small Cell Lung Cancer Xenografts

Kentaro Fujiwara, Keitaro Koyama, Kousuke Suga, +11

PLoS ONE

A 90Y-labelled anti-ROBO1 monoclonal antibody exhibits antitumour activity against hepatocellular carcinoma xenografts during ROBO1-targeted radioimmunotherapy

Kentaro Fujiwara, Keitaro Koyama, Kousuke Suga, +11

EJNMMI Research

A Low-Dose β1-Blocker in Combination with Milrinone Improves Intracellular Ca2+ Handling in Failing Cardiomyocytes by Inhibition of Milrinone-Induced Diastolic Ca2+ Leakage from the Sarcoplasmic Reticulum

Shigeki Kobayashi, Takehisa Susa, Hironori Ishiguchi, +15

PLoS ONE