Huawei Chen

The JAK2 Inhibitor AZD1480 Potently Blocks Stat3 Signaling and Oncogenesis in Solid Tumors

Michael Hedvat, Dennis Huszar, Andreas Herrmann et al. · Cancer Cell · 2009 · 526 citations · Full text

Tumor Biology, Signaling Pathway, Solid Tumors +8

BRD4 Inhibition Is Synthetic Lethal with PARP Inhibitors through the Induction of Homologous Recombination Deficiency

Chaoyang Sun, Jun‐Jie Yin, Yong Fang et al. · Cancer Cell · 2018 · 295 citations · Full text

Homologous Recombination Deficiency, Engineering, Molecular Biology +6

AZD1208, a potent and selective pan-Pim kinase inhibitor, demonstrates efficacy in preclinical models of acute myeloid leukemia

Erika Krasnickas Keeton, Kristen McEachern, Keith Dillman et al. · Blood · 2013 · 240 citations

Structural Basis of Substrate Methylation and Inhibition of SMYD2

Andrew D. Ferguson, Nicholas Larsen, Tina Howard et al. · Structure · 2011 · 193 citations · Full text

Biochemistry, Natural Sciences, Epigenetic Change +7

<i>mom</i> identifies a receptor for the <i>Drosophila</i> JAK/STAT signal transduction pathway and encodes a protein distantly related to the mammalian cytokine receptor family

Huawei Chen, Xiu Chen, Su‐Wan Oh et al. · Genes & Development · 2002 · 171 citations · Full text

Developmental Biology, Signal Transduction, Signaling Pathway +12