A Chemoproteomic Approach to Query the Degradable Kinome Using a Multi-kinase Degrader

Hai‐Tsang Huang, Dennis Dobrovolsky, Joshiawa Paulk, +16

Cell chemical biology

Protein FunctionChemoproteomic ApproachStructural BioinformaticsProtein FoldingMedicine +11

Mapping the Degradable Kinome Provides a Resource for Expedited Degrader Development

Katherine A. Donovan, Fleur M. Ferguson, Jonathan W. Bushman, +31

Cell

Geometric ModelingRoboticsEngineeringExpedited Degrader DevelopmentNatural Sciences +9

A virus-targeted plant receptor-like kinase promotes cell-to-cell spread of RNAi

Tábata Rosas‐Díaz, Dan Zhang, Pengfei Fan, +17

Proceedings of the National Academy of Sciences

The IkappaB Kinase Family Phosphorylates the Parkinson’s Disease Kinase LRRK2 at Ser935 and Ser910 during Toll-Like Receptor Signaling

Nicolas Dzamko, Francisco Iñesta-Vaquera, Jiazhen Zhang, +10

PLoS ONE

Innate Immune SystemImmunologyImmune RegulationToll-like ReceptorImmunologic Mechanism +18

Chemically Induced Degradation of Anaplastic Lymphoma Kinase (ALK)

Chelsea E. Powell, Yang Gao, Li Tan, +8

Journal of Medicinal Chemistry

Lymphoid NeoplasiaInduced DegradationAurora AMedicineOncogenic Agent +11

Development of covalent inhibitors that can overcome resistance to first-generation FGFR kinase inhibitors

Li Tan, Jun Wang, Junko Tanizaki, +20

Proceedings of the National Academy of Sciences

Covalent InhibitorsFgfr InhibitorsHuman Fgf ReceptorsMolecular BiologyPharmacotherapy +16

Arsenic targets Pin1 and cooperates with retinoic acid to inhibit cancer-driving pathways and tumor-initiating cells

Shingo Kozono, Yu‐Min Lin, Hyuk‐Soo Seo, +14

Nature Communications

Docosahexaenoic acid changes lipid composition and interleukin-2 receptor signaling in membrane rafts

Qiurong Li, Meng Wang, Li Tan, +6

Journal of Lipid Research

Proteinlipid InteractionLipid PeroxidationImmunologyImmune RegulationInnate Immunity +19

Discovery of a Potent and Selective DDR1 Receptor Tyrosine Kinase Inhibitor

Hyung-Gu Kim, Li Tan, Ellen Weisberg, +13

ACS Chemical Biology

Drug TargetMolecular BiologyCytoskeletonPharmacotherapySignaling Pathway +18

Suppression of Adaptive Responses to Targeted Cancer Therapy by Transcriptional Repression

Maria Rusan, Kapsok Li, Yvonne Li, +30

Cancer Discovery