Shen Wang

An inhibitor of Bcl-2 family proteins induces regression of solid tumours

Tilman Oltersdorf, Steven W. Elmore, Alexander R. Shoemaker et al. · Nature · 2005 · 3.4K citations

Tumor Biology, Bcl-2 Family Proteins, Medicine +9

Allosteric inhibition of protein tyrosine phosphatase 1B

Christian Wiesmann, Kenneth J. Barr, Jenny Kung et al. · Nature Structural & Molecular Biology · 2004 · 519 citations

Allosteric Inhibition, Signal Transduction, Biochemistry +5

Discovery of a Potent Inhibitor of the Antiapoptotic Protein Bcl-x _L from NMR and Parallel Synthesis

Andrew M. Petros, Jürgen Dinges, David J. Augeri et al. · Journal of Medicinal Chemistry · 2005 · 291 citations

Design of target specific peptide inhibitors using generative deep learning and molecular dynamics simulations

Sijie Chen, Tong Lin, Ruchira Basu et al. · Nature Communications · 2024 · 249 citations · Full text

Structure-Guided Design, Synthesis, and Evaluation of Guanine-Derived Inhibitors of the eIF4E mRNA–Cap Interaction

Xiaoqi Chen, David J. Kopecky, Jeff Mihalic et al. · Journal of Medicinal Chemistry · 2012 · 218 citations · Full text

Molecular Biology, Chemical Biology, Protein Synthesis +17