Ioanna Deni

Plasmodium falciparum K13 mutations in Africa and Asia impact artemisinin resistance and parasite fitness

Barbara H. Stokes, Satish K. Dhingra, Kelly Rubiano et al. · eLife · 2021 · 175 citations · Full text

Life Sciences, Genetics, Infectious Diseases +16

Potent Antimalarials with Development Potential Identified by Structure-Guided Computational Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series

Michael Palmer, Xiaoyi Deng, Shawn Watts et al. · Journal of Medicinal Chemistry · 2021 · 46 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Design of proteasome inhibitors with oral efficacy in vivo against <i>Plasmodium falciparum</i> and selectivity over the human proteasome

Stanley C. Xie, Riley D. Metcalfe, Hirotake Mizutani et al. · Proceedings of the National Academy of Sciences · 2021 · 37 citations · Full text

Life Sciences, Biochemistry, Medicinal Chemistry +17

Evidence for the early emergence of piperaquine-resistant Plasmodium falciparum malaria and modeling strategies to mitigate resistance

Jennifer L. Small-Saunders, Laura M. Hagenah, Kathryn J. Wicht et al. · PLoS Pathogens · 2022 · 31 citations · Full text

Life Sciences, Infectious Diseases, Molecular Genetics +17

Safety, pharmacokinetics, and antimalarial activity of the novel triaminopyrimidine ZY-19489: a first-in-human, randomised, placebo-controlled, double-blind, single ascending dose study, pilot food-effect study, and volunteer infection study.

Bridget E. Barber, Melissa Fernandez, Hardik B. Patel et al. · LSTM Online Archive (Liverpool School of Tropical Medicine) · 2022 · 30 citations

Medicine, Pharmacokinetics, Pharmacology +16