Hirotake Mizutani

An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer

Teresa A. Soucy, Peter G. Smith, Michael A. Milhollen et al. · Nature · 2009 · 2K citations

Medicine, Medicinal Chemistry, Oncology +8

Modular Peptide-Based Phosphine Ligands in Asymmetric Catalysis:  Efficient and Enantioselective Cu-Catalyzed Conjugate Additions to Five-, Six-, and Seven-Membered Cyclic Enones

Sylvia J. Degrado, Hirotake Mizutani, Amir H. Hoveyda · Journal of the American Chemical Society · 2001 · 250 citations

Natural Sciences, Chemistry, Catalysis +7

Probing the roles of SUMOylation in cancer cell biology by using a selective SAE inhibitor

Xingyue He, Jessica Riceberg, Teresa A. Soucy et al. · Nature Chemical Biology · 2017 · 229 citations

Medicine, Cancer Biology, Molecular Biology +8

Discovery of TAK-981, a First-in-Class Inhibitor of SUMO-Activating Enzyme for the Treatment of Cancer

Steven Langston, Stephen Grossman, Dylan B. England et al. · Journal of Medicinal Chemistry · 2021 · 208 citations · Full text

Pharmacy, Medicinal Chemistry, Oncology +11

Cu-Catalyzed Asymmetric Conjugate Additions of Alkylzinc Reagents to Acyclic Aliphatic Enones

Hirotake Mizutani, Sylvia J. Degrado, Amir H. Hoveyda · Journal of the American Chemical Society · 2002 · 193 citations

Natural Sciences, Chemistry, Catalysis +11