Hirotake Mizutani

An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer

Teresa A. Soucy, Peter G. Smith, Michael A. Milhollen et al. · Nature · 2009 · 2K citations

Novel Therapy, Medicine, New Approach +9

Modular Peptide-Based Phosphine Ligands in Asymmetric Catalysis:  Efficient and Enantioselective Cu-Catalyzed Conjugate Additions to Five-, Six-, and Seven-Membered Cyclic Enones

Sylvia J. Degrado, Hirotake Mizutani, Amir H. Hoveyda · Journal of the American Chemical Society · 2001 · 249 citations

Asymmetric Catalysis, Engineering, Conjugate Acid-base Pairs +12

Probing the roles of SUMOylation in cancer cell biology by using a selective SAE inhibitor

Xingyue He, Jessica Riceberg, Teresa A. Soucy et al. · Nature Chemical Biology · 2017 · 223 citations

Selective Sae Inhibitor, Oncogenic Agent, Medicine +10

Discovery of TAK-981, a First-in-Class Inhibitor of SUMO-Activating Enzyme for the Treatment of Cancer

Steven Langston, Stephen Grossman, Dylan B. England et al. · Journal of Medicinal Chemistry · 2021 · 194 citations · Full text

Cu-Catalyzed Asymmetric Conjugate Additions of Alkylzinc Reagents to Acyclic Aliphatic Enones

Hirotake Mizutani, Sylvia J. Degrado, Amir H. Hoveyda · Journal of the American Chemical Society · 2002 · 193 citations

Novel Organocatalysts, Additional C-c Bond, Engineering +14