Xiaoyi Deng

A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria

Margaret A. Phillips, Julie Lotharius, Kennan C. Marsh et al. · Science Translational Medicine · 2015 · 367 citations

Structure-Guided Lead Optimization of Triazolopyrimidine-Ring Substituents Identifies Potent<i>Plasmodium falciparum</i>Dihydroorotate Dehydrogenase Inhibitors with Clinical Candidate Potential

José M. Coterón, María Marco, Jorge Esquivias et al. · Journal of Medicinal Chemistry · 2011 · 280 citations · Full text

Lead Optimization of Aryl and Aralkyl Amine-Based Triazolopyrimidine Inhibitors of<i>Plasmodium falciparum</i>Dihydroorotate Dehydrogenase with Antimalarial Activity in Mice

Ramesh Gujjar, Farah El Mazouni, Karen L. White et al. · Journal of Medicinal Chemistry · 2011 · 165 citations · Full text

Novel Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase with Anti-malarial Activity in the Mouse Model*

Michael L. Booker, Cecilia M. Bastos, Martin Kramer et al. · Journal of Biological Chemistry · 2010 · 134 citations · Full text

Structural Plasticity of Malaria Dihydroorotate Dehydrogenase Allows Selective Binding of Diverse Chemical Scaffolds

Xiaoyi Deng, Ramesh Gujjar, Farah El Mazouni et al. · Journal of Biological Chemistry · 2009 · 122 citations · Full text