DHODH modulates transcriptional elongation in the neural crest and melanoma

Richard M. White, Jennifer N. Cech, Sutheera Ratanasirintrawoot, +17

Nature

Transcriptional RegulationDevelopmental BiologyCell RegulationMelanomaMorphogenesis +4

Novel Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase with Anti-malarial Activity in the Mouse Model*

Michael L. Booker, Cecilia M. Bastos, Martin Kramer, +27

Journal of Biological Chemistry

TTC staining of damaged brain areas after MCA occlusion in the rat does not constrict quantitative gene and protein analyses

Martin Kramer, Jon Dang, Fabian Baertling, +5

Journal of Neuroscience Methods

Quantitative GeneMca OcclusionNeuroanatomyPathologyBrain Injury +9

Identification and Characterization of Small Molecule Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase

Vishal Patel, Michael L. Booker, Martin Kramer, +8

Journal of Biological Chemistry

Diversity-Oriented Synthesis Yields a Novel Lead for the Treatment of Malaria

Richard W. Heidebrecht, Carol A. Mulrooney, Christopher P. Austin, +28

ACS Medicinal Chemistry Letters

Neuroinflammation in neuronopathic Gaucher disease: Role of microglia and NK cells, biomarkers, and response to substrate reduction therapy

Chandra Sekhar Boddupalli, Shiny Nair, Glenn S. Belinsky, +14

eLife

Transmembrane protease serine 5: a novel Schwann cell plasma marker for CMT1A

Hongge Wang, Matt Davison, Kathryn Wang, +16

Annals of Clinical and Translational Neurology

Optimization of Potent Inhibitors of <i>P. falciparum</i> Dihydroorotate Dehydrogenase for the Treatment of Malaria

Renato T. Skerlj, Cecilia M. Bastos, Michael L. Booker, +12

ACS Medicinal Chemistry Letters

Medicinal ChemistryBioorganic ChemistryHuman EnzymeBiochemistryAntiparasitic Agent +13

Cofactor-Independent Phosphoglycerate Mutase from Nematodes Has Limited Druggability, as Revealed by Two High-Throughput Screens

Gregory J. Crowther, Michael L. Booker, Min He, +11

PLoS neglected tropical diseases

Identification of<i>Trypanosoma brucei</i>AdoMetDC Inhibitors Using a High-Throughput Mass Spectrometry-Based Assay

Oleg A. Volkov, Casey C. Cosner, Anthony J. Brockway, +14

ACS Infectious Diseases