Mutant Huntingtin Disrupts the Nuclear Pore Complex

Jonathan C. Grima, J. Gavin Daigle, Nicolas Arbez, +20

Neuron

Natural SciencesMolecular BiologyNuclear OrganizationMutant Huntingtin DisruptsCellular Biochemistry

Neuroprotective role of Sirt1 in mammalian models of Huntington's disease through activation of multiple Sirt1 targets

Mali Jiang, Jiawei Wang, Jinrong Fu, +27

Nature Medicine

Mammalian ModelsGeneticsCell DeathDegenerative PathologyNeuroprotection +6

Developmental alterations in Huntington's disease neural cells and pharmacological rescue in cells and mice

Ryan G. Lim, Lisa Salazar, Daniel K. Wilton, +48

Nature Neuroscience

NeuroregenerationDevelopmental BiologyMolecular NeuroscienceDevelopmental AlterationsMedicine +11

trans-(−)-ε-Viniferin Increases Mitochondrial Sirtuin 3 (SIRT3), Activates AMP-activated Protein Kinase (AMPK), and Protects Cells in Models of Huntington Disease

Jinrong Fu, Jing Jin, Robert H. Cichewicz, +9

Journal of Biological Chemistry

Neurodegenerative DiseasesSystems BiologyMolecular PhysiologySignal TransductionMitochondrial Function +11

Huntingtin protein interactions altered by polyglutamine expansion as determined by quantitative proteomic analysis

Tamara Ratovitski, Ekaterine Chighladze, Nicolas Arbez, +4

Cell Cycle

Huntingtin Protein InteractionsMitochondrial DysfunctionMolecular BiologyQuantitative Proteomic AnalysisProtein Folding +16

Identification of Novel Potentially Toxic Oligomers Formed in Vitro from Mammalian-derived Expanded huntingtin Exon-1 Protein

Leslie G. Nucifora, Kathleen A. Burke, Xia Feng, +11

Journal of Biological Chemistry

PPAR-δ is repressed in Huntington's disease, is required for normal neuronal function and can be targeted therapeutically

Audrey S. Dickey, Victor V. Pineda, Taiji Tsunemi, +20

Nature Medicine

Neurodegenerative DiseasesNeurobiology Of DiseaseMolecular NeuroscienceExperimental NeuropathologyNeuroscience +7

N6-Furfuryladenine is protective in Huntington’s disease models by signaling huntingtin phosphorylation

Laura E. Bowie, Tamara Maiuri, Melanie Alpaugh, +11

Proceedings of the National Academy of Sciences

Ubiqutination via K27 and K29 chains signals aggregation and neuronal protection of LRRK2 by WSB1

Frederick C. Nucifora, Leslie G. Nucifora, Chee H. Ng, +16

Nature Communications

PPARδ activation by bexarotene promotes neuroprotection by restoring bioenergetic and quality control homeostasis

Audrey S. Dickey, Dafne N. Sanchez, Martin Arreola Villanueva, +16

Science Translational Medicine