Makenna M. Morck

Deciphering the super relaxed state of human β-cardiac myosin and the mode of action of mavacamten from myosin molecules to muscle fibers

Robert L. Anderson, Darshan V. Trivedi, Saswata S. Sarkar et al. · Proceedings of the National Academy of Sciences · 2018 · 408 citations · Full text

Life Sciences, Biochemistry, Physiology +17

Recurrent RNA motifs as scaffolds for genetically encodable small-molecule biosensors

Ely Porter, Jacob T. Polaski, Makenna M. Morck et al. · Nature Chemical Biology · 2017 · 134 citations

Engineering, Bioengineering, Molecular Biology +14

The hypertrophic cardiomyopathy mutations R403Q and R663H increase the number of myosin heads available to interact with actin

Saswata S. Sarkar, Darshan V. Trivedi, Makenna M. Morck et al. · Science Advances · 2020 · 100 citations · Full text

Life Sciences, Genetics, Molecular Biology +16

Hypertrophic cardiomyopathy β-cardiac myosin mutation (P710R) leads to hypercontractility by disrupting super relaxed state

Alison Schroer Vander Roest, Chao Liu, Makenna M. Morck et al. · Proceedings of the National Academy of Sciences · 2021 · 82 citations · Full text

Natural Sciences, Biophysics, Cardiology +17

Hypertrophic cardiomyopathy mutations in the pliant and light chain-binding regions of the lever arm of human β-cardiac myosin have divergent effects on myosin function

Makenna M. Morck, Debanjan Bhowmik, Divya Pathak et al. · eLife · 2022 · 24 citations · Full text

Life Sciences, Molecular Biology, Molecular Genetics +13