Makenna M. Morck

Deciphering the super relaxed state of human β-cardiac myosin and the mode of action of mavacamten from myosin molecules to muscle fibers

Robert L. Anderson, Darshan V. Trivedi, Saswata S. Sarkar et al. · Proceedings of the National Academy of Sciences · 2018 · 392 citations · Full text

Cardiac Muscle, Muscle Function, Molecular Biology +22

Recurrent RNA motifs as scaffolds for genetically encodable small-molecule biosensors

Ely Porter, Jacob T. Polaski, Makenna M. Morck et al. · Nature Chemical Biology · 2017 · 129 citations · Full text

Engineering, Nucleic Acid Biomarkers, Rna Structure Prediction +11

The hypertrophic cardiomyopathy mutations R403Q and R663H increase the number of myosin heads available to interact with actin

Saswata S. Sarkar, Darshan V. Trivedi, Makenna M. Morck et al. · Science Advances · 2020 · 96 citations · Full text

Hypertrophic cardiomyopathy β-cardiac myosin mutation (P710R) leads to hypercontractility by disrupting super relaxed state

Alison Schroer Vander Roest, Chao Liu, Makenna M. Morck et al. · Proceedings of the National Academy of Sciences · 2021 · 76 citations · Full text

Hypertrophic cardiomyopathy mutations in the pliant and light chain-binding regions of the lever arm of human β-cardiac myosin have divergent effects on myosin function

Makenna M. Morck, Debanjan Bhowmik, Divya Pathak et al. · eLife · 2022 · 22 citations · Full text

Cardiac Muscle, Molecular Biology, Cytoskeleton +19