Darshan V. Trivedi

Deciphering the super relaxed state of human β-cardiac myosin and the mode of action of mavacamten from myosin molecules to muscle fibers

Robert L. Anderson, Darshan V. Trivedi, Saswata S. Sarkar et al. · Proceedings of the National Academy of Sciences · 2018 · 408 citations · Full text

Life Sciences, Biochemistry, Physiology +17

The myosin mesa and the basis of hypercontractility caused by hypertrophic cardiomyopathy mutations

Suman Nag, Darshan V. Trivedi, Saswata S. Sarkar et al. · Nature Structural & Molecular Biology · 2017 · 233 citations

Medicine, Cardiology, Genetics +13

SETD3 is an actin histidine methyltransferase that prevents primary dystocia

Alex W. Wilkinson, Jonathan Diep, Shaobo Dai et al. · Nature · 2018 · 172 citations

Life Sciences, Cell Biology, Molecular Biology +7

The hypertrophic cardiomyopathy mutations R403Q and R663H increase the number of myosin heads available to interact with actin

Saswata S. Sarkar, Darshan V. Trivedi, Makenna M. Morck et al. · Science Advances · 2020 · 100 citations · Full text

Life Sciences, Genetics, Molecular Biology +16

β-Cardiac myosin hypertrophic cardiomyopathy mutations release sequestered heads and increase enzymatic activity

Arjun S. Adhikari, Darshan V. Trivedi, Saswata S. Sarkar et al. · Nature Communications · 2019 · 90 citations · Full text

Life Sciences, Cardiology, Molecular Biology +14