Darshan V. Trivedi

Deciphering the super relaxed state of human β-cardiac myosin and the mode of action of mavacamten from myosin molecules to muscle fibers

Robert L. Anderson, Darshan V. Trivedi, Saswata S. Sarkar et al. · Proceedings of the National Academy of Sciences · 2018 · 392 citations · Full text

Cardiac Muscle, Muscle Function, Molecular Biology +22

The myosin mesa and the basis of hypercontractility caused by hypertrophic cardiomyopathy mutations

Suman Nag, Darshan V. Trivedi, Saswata S. Sarkar et al. · Nature Structural & Molecular Biology · 2017 · 225 citations · Full text

Cardiac Muscle, Cardiomyopathy, Heart Failure +11

SETD3 is an actin histidine methyltransferase that prevents primary dystocia

Alex W. Wilkinson, Jonathan Diep, Shaobo Dai et al. · Nature · 2018 · 166 citations

Chromatin, Genetic Disorder, Actin Histidine Methyltransferase +8

The hypertrophic cardiomyopathy mutations R403Q and R663H increase the number of myosin heads available to interact with actin

Saswata S. Sarkar, Darshan V. Trivedi, Makenna M. Morck et al. · Science Advances · 2020 · 96 citations · Full text

β-Cardiac myosin hypertrophic cardiomyopathy mutations release sequestered heads and increase enzymatic activity

Arjun S. Adhikari, Darshan V. Trivedi, Saswata S. Sarkar et al. · Nature Communications · 2019 · 86 citations · Full text