Molecular Tension Sensors Report Forces Generated by Single Integrin Molecules in Living Cells

Masatoshi Morimatsu, Armen H. Mekhdjian, Arjun S. Adhikari, +1

Nano Letters

Cell AdhesionMolecular BiologyCytoskeletonCell BiophysicsCell Mechanics +17

The myosin mesa and the basis of hypercontractility caused by hypertrophic cardiomyopathy mutations

Suman Nag, Darshan V. Trivedi, Saswata S. Sarkar, +5

Nature Structural & Molecular Biology

Cardiac MuscleCardiomyopathyHeart FailureMolecular PhysiologyPhysiology +9

Mechanical Load Induces a 100-Fold Increase in the Rate of Collagen Proteolysis by MMP-1

Arjun S. Adhikari, Jack Chai, Alexander R. Dunn

Journal of the American Chemical Society

Tissue EngineeringEngineeringBiomimetic MaterialsBone RepairMechanotransduction +19

Mechanical Load Induces a 100-Fold Increase in the Rate of Collagen Proteolysis by MMP-1

Arjun S. Adhikari, Jack Chai, Alexander R. Dunn

Biophysical Journal

MechanobiologyTissue EngineeringFibrosisEngineeringBone Repair +8

The hypertrophic cardiomyopathy mutations R403Q and R663H increase the number of myosin heads available to interact with actin

Saswata S. Sarkar, Darshan V. Trivedi, Makenna M. Morck, +4

Science Advances

Early-Onset Hypertrophic Cardiomyopathy Mutations Significantly Increase the Velocity, Force, and Actin-Activated ATPase Activity of Human β-Cardiac Myosin

Arjun S. Adhikari, Kristina B. Kooiker, Saswata S. Sarkar, +4

Cell Reports

Cardiac MuscleHeart FailureEngineeringMolecular BiologyCytoskeleton +20

β-Cardiac myosin hypertrophic cardiomyopathy mutations release sequestered heads and increase enzymatic activity

Arjun S. Adhikari, Darshan V. Trivedi, Saswata S. Sarkar, +5

Nature Communications

Mechanical coordination in motor ensembles revealed using engineered artificial myosin filaments

Rizal F. Hariadi, Ruth F. Sommese, Arjun S. Adhikari, +4

Nature Nanotechnology

EngineeringMechanical EngineeringMotor ControlMechanotransductionCytoskeleton +14

A cytoskeletal clutch mediates cellular force transmission in a soft, three-dimensional extracellular matrix

Leanna M. Owen, Arjun S. Adhikari, Mohak Patel, +6

Molecular Biology of the Cell

EngineeringBiomimetic MaterialsCell AdhesionBiofabricationCytoskeleton +20

Conformational Dynamics Accompanying the Proteolytic Degradation of Trimeric Collagen I by Collagenases

Arjun S. Adhikari, Emerson Glassey, Alexander R. Dunn

Journal of the American Chemical Society

Conformational DynamicsProtein AssemblyMolecular BiologyCytoskeletonProtein Refolding +20