Saswata S. Sarkar

Deciphering the super relaxed state of human β-cardiac myosin and the mode of action of mavacamten from myosin molecules to muscle fibers

Robert L. Anderson, Darshan V. Trivedi, Saswata S. Sarkar et al. · Proceedings of the National Academy of Sciences · 2018 · 408 citations · Full text

Life Sciences, Biochemistry, Physiology +17

The myosin mesa and the basis of hypercontractility caused by hypertrophic cardiomyopathy mutations

Suman Nag, Darshan V. Trivedi, Saswata S. Sarkar et al. · Nature Structural & Molecular Biology · 2017 · 233 citations

Medicine, Cardiology, Genetics +13

The hypertrophic cardiomyopathy mutations R403Q and R663H increase the number of myosin heads available to interact with actin

Saswata S. Sarkar, Darshan V. Trivedi, Makenna M. Morck et al. · Science Advances · 2020 · 100 citations · Full text

Life Sciences, Genetics, Molecular Biology +16

Early-Onset Hypertrophic Cardiomyopathy Mutations Significantly Increase the Velocity, Force, and Actin-Activated ATPase Activity of Human β-Cardiac Myosin

Arjun S. Adhikari, Kristina B. Kooiker, Saswata S. Sarkar et al. · Cell Reports · 2016 · 94 citations · Full text

Natural Sciences, Cardiology, Genetics +17

β-Cardiac myosin hypertrophic cardiomyopathy mutations release sequestered heads and increase enzymatic activity

Arjun S. Adhikari, Darshan V. Trivedi, Saswata S. Sarkar et al. · Nature Communications · 2019 · 90 citations · Full text

Life Sciences, Cardiology, Molecular Biology +14