B12 cofactors directly stabilize an mRNA regulatory switch

J.E. Johnson, F.E. Reyes, Jacob T. Polaski, +1

Nature

Transcription RegulationGene RegulationGene ExpressionMedicineCell Biology +1

A multicolor riboswitch-based platform for imaging of RNA in live mammalian cells

Esther Braselmann, Aleksandra J. Wierzba, Jacob T. Polaski, +10

Nature Chemical Biology

Multicolor Riboswitch-based PlatformEngineeringNatural SciencesRna Structure PredictionBiomedical Imaging +7

Recurrent RNA motifs as scaffolds for genetically encodable small-molecule biosensors

Ely Porter, Jacob T. Polaski, Makenna M. Morck, +1

Nature Chemical Biology

EngineeringNucleic Acid BiomarkersRna Structure PredictionRna BiologySynthetic Biology +9

RNA isoform screens uncover the essentiality and tumor-suppressor activity of ultraconserved poison exons

James D. Thomas, Jacob T. Polaski, Qing Feng, +10

Nature Genetics

Natural SciencesTumor-suppressor ActivityMolecular BiologyLong Non-coding RnaAntisense Therapy +4

Minor intron retention drives clonal hematopoietic disorders and diverse cancer predisposition

Daichi Inoue, Jacob T. Polaski, Justin Taylor, +25

Nature Genetics

Tumor HeterogeneityMedicineDiverse Cancer PredispositionPathologyCancer Genomics +7

Synthetic introns enable splicing factor mutation-dependent targeting of cancer cells

Khrystyna North, Salima Benbarche, Bo Liu, +17

Nature Biotechnology

Rna ProcessingMedicineCancer Cell BiologyCancer GenomicsCancer Genetics +8

Cobalamin riboswitches exhibit a broad range of ability to discriminate between methylcobalamin and adenosylcobalamin

Jacob T. Polaski, Samantha M. Webster, J.E. Johnson, +1

Journal of Biological Chemistry

Broad RangeBiochemistryMedicineMicrobiologyMetabolomics +2

Single-Molecule Conformational Dynamics of a Biologically Functional Hydroxocobalamin Riboswitch

Erik D. Holmstrom, Jacob T. Polaski, Robert Batey, +1

Journal of the American Chemical Society

BiochemistryProtein AssemblyProtein FoldingNatural SciencesBiomolecular Structure Prediction +13

Mechanistic Insights into Cofactor-Dependent Coupling of RNA Folding and mRNA Transcription/Translation by a Cobalamin Riboswitch

Jacob T. Polaski, Erik D. Holmstrom, David J. Nesbitt, +1

Cell Reports

Rare and private spliceosomal gene mutations drive partial, complete, and dual phenocopies of hotspot alterations

Joseph Pangallo, Jean‐Jacques Kiladjian, Bruno Cassinat, +6

Blood