Integrated barcode chips for rapid, multiplexed analysis of proteins in microliter quantities of blood

Rong Fan, Ophir Vermesh, Alok Srivastava, +8

Nature Biotechnology

EngineeringMedicineBioanalysisAnalytical MicrosystemsLaboratory Medicine +13

A clinical microchip for evaluation of single immune cells reveals high functional heterogeneity in phenotypically similar T cells

Chao Ma, Rong Fan, Habib Ahmad, +9

Nature Medicine

Autoimmune DiseaseMedicineT-regulatory CellImmunologyAutoimmunity +7

SETD3 is an actin histidine methyltransferase that prevents primary dystocia

Alex W. Wilkinson, Jonathan Diep, Shaobo Dai, +19

Nature

ChromatinGenetic DisorderActin Histidine MethyltransferaseGeneticsMedicine +6

Early-Onset Hypertrophic Cardiomyopathy Mutations Significantly Increase the Velocity, Force, and Actin-Activated ATPase Activity of Human β-Cardiac Myosin

Arjun S. Adhikari, Kristina B. Kooiker, Saswata S. Sarkar, +4

Cell Reports

Cardiac MuscleHeart FailureEngineeringMolecular BiologyCytoskeleton +20

Controlling load-dependent kinetics of β-cardiac myosin at the single-molecule level

Chao Liu, Masataka Kawana, Dan Song, +2

Nature Structural & Molecular Biology

Cardiac MuscleBiophysical ModelingMolecular Physiologyβ-Cardiac MyosinPhysiology +4

Hypertrophic cardiomyopathy β-cardiac myosin mutation (P710R) leads to hypercontractility by disrupting super relaxed state

Alison Schroer Vander Roest, Chao Liu, Makenna M. Morck, +14

Proceedings of the National Academy of Sciences

The nucleoprotein of severe fever with thrombocytopenia syndrome virus processes a stable hexameric ring to facilitate RNA encapsidation

Honggang Zhou, Yuna Sun, Ying Wang, +9

Protein & Cell

Electrochemiluminescent determination of the activity of uracil-DNA glycosylase: Combining nicking enzyme assisted signal amplification and catalyzed hairpin assembly

Qiao Liu, Chao Liu, Guang Zhu, +6

Microchimica Acta

BiochemistryNatural SciencesBioanalysisUracil-dna GlycosylaseHairpin Assembly +5

Lysine methylation promotes NFAT5 activation and determines temozolomide efficacy in glioblastoma

Yatian Li, Zhenyue Gao, Yuhong Wang, +12

Nature Communications