Structure Based Drug Design of Crizotinib (PF-02341066), a Potent and Selective Dual Inhibitor of Mesenchymal–Epithelial Transition Factor (c-MET) Kinase and Anaplastic Lymphoma Kinase (ALK)

J. Jean Cui, Michelle Tran‐Dubé, Hong Shen, +21

Journal of Medicinal Chemistry

Drug TargetLead SeriesChemical BiologyAnaplastic Lymphoma KinasePharmaceutical Chemistry +18

Discovery of a Novel Class of Exquisitely Selective Mesenchymal-Epithelial Transition Factor (c-MET) Protein Kinase Inhibitors and Identification of the Clinical Candidate 2-(4-(1-(Quinolin-6-ylmethyl)-1 <i>H</i> -[1,2,3]triazolo[4,5- <i>b</i> ]pyrazin-6-yl)-1 <i>H</i> -pyrazol-1-yl)ethanol (PF-04217903) for the Treatment of Cancer

J. Jean Cui, Michele McTigue, Mitchell D. Nambu, +20

Journal of Medicinal Chemistry

Discovery of <i>N</i>-((3<i>R</i>,4<i>R</i>)-4-Fluoro-1-(6-((3-methoxy-1-methyl-1<i>H</i>-pyrazol-4-yl)amino)-9-methyl-9<i>H</i>-purin-2-yl)pyrrolidine-3-yl)acrylamide (PF-06747775) through Structure-Based Drug Design: A High Affinity Irreversible Inhibitor Targeting Oncogenic EGFR Mutants with Selectivity over Wild-Type EGFR

Simon Planken, Douglas C. Behenna, Sajiv K. Nair, +38

Journal of Medicinal Chemistry

Molecular BiologyWild-type EgfrChemical BiologyTumor BiologyMolecular Pharmacology +19

Systematic Structure Modifications of Imidazo[1,2-<i>a</i>]pyrimidine to Reduce Metabolism Mediated by Aldehyde Oxidase (AO)

Angelica Linton, Ping Kang, Martha A. Ornelas, +5

Journal of Medicinal Chemistry

Androgen ReceptorBioorganic ChemistryMolecular BiologyPharmacotherapyChemical Biology +20

The Antibody Registry: ten years of registering antibodies

Anita Bandrowski, Mason Pairish, Peter Eckmann, +2

Nucleic Acids Research

ImmunologyPathologyAntibody RegistryImmunotherapyBioinformatics Database +14

Discovery of Aryloxy Tetramethylcyclobutanes as Novel Androgen Receptor Antagonists

Chuangxing Guo, Angelica Linton, Susan E. Kephart, +26

Journal of Medicinal Chemistry

An Extended β-Strand Mimic for a Larger Artificial β-Sheet

James S. Nowick, Mason Pairish, In Quen Lee, +2

Journal of the American Chemical Society

Materials SciencePharmaceutical ChemistryEngineeringMacromolecular ArchitectureBiochemistry +11

Discovery of 2-((1H-benzo[d]imidazol-1-yl)methyl)-4H-pyrido[1,2-a]pyrimidin-4-ones as novel PKM2 activators

Chuangxing Guo, Angelica Linton, Mehran Jalaie, +10

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryMedicineNovel Pkm2 ActivatorsPharmacologyPharmaceutical Chemistry +1

Structure-Based Drug Design and Synthesis of PI3Kα-Selective Inhibitor (PF-06843195)

Hengmiao Cheng, Suvi T. M. Orr, Simon Bailey, +36

Journal of Medicinal Chemistry

Structure-based design, SAR analysis and antitumor activity of PI3K/mTOR dual inhibitors from 4-methylpyridopyrimidinone series

Hengmiao Cheng, Jacqui Hoffman, Phuong Le, +10

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryDrug TargetMedicineDrug DiscoverySar Analysis +10