Edward L. Fritzen

3-Aminopyrazole Inhibitors of CDK2/Cyclin A as Antitumor Agents. 1. Lead Finding

Paolo Pevarello, Maria Gabriella Brasca, Raffaella Amici et al. · Journal of Medicinal Chemistry · 2004 · 157 citations · Full text

Drug Target, Lead Identification, Pharmacotherapy +23

Synthesis of a Series of Stromelysin-Selective Thiadiazole Urea Matrix Metalloproteinase Inhibitors

E. Jon Jacobsen, Mark A. Mitchell, Susan K. Hendges et al. · Journal of Medicinal Chemistry · 1999 · 57 citations · Full text

Medicinal Chemistry, Amino Acid Component, Bioorganic Chemistry +14

Photocycloaddition chemistry of 2-(trimethylsilyl)cyclopentenone and 5-(trimethylsilyl)uracil. The utility of a trimethylsilyl group as a removable directing group in photochemistry

Chaun Shih, Edward L. Fritzen, John S. Swenton · The Journal of Organic Chemistry · 1980 · 53 citations

Engineering, Photoredox Process, Biochemistry +13

Discovery and Optimization of Quinolinone Derivatives as Potent, Selective, and Orally Bioavailable Mutant Isocitrate Dehydrogenase 1 (mIDH1) Inhibitors

Jian Lin, Wei Lu, Justin A. Caravella et al. · Journal of Medicinal Chemistry · 2019 · 46 citations · Full text

Allene formation in reactions of propargyl chlorides with dialkylcuprates and alkylallenylcuprates

Daniel J. Pasto, Shine-King Chou, Edward L. Fritzen et al. · The Journal of Organic Chemistry · 1978 · 31 citations

Propargyl Chlorides, Novel Organocatalysts, Chemical Measurement +14