Susan K. Hendges

Synthesis and Antibacterial Activity of U-100592 and U-100766, Two Oxazolidinone Antibacterial Agents for the Potential Treatment of Multidrug-Resistant Gram-Positive Bacterial Infections

Steven J. Brickner, Douglas K. Hutchinson, Michael R. Barbachyn et al. · Journal of Medicinal Chemistry · 1996 · 570 citations

Antibacterial Activity, Antimicrobial Chemotherapy, Drug Resistance +16

Identification of a Novel Oxazolidinone (U-100480) with Potent Antimycobacterial Activity

Michael R. Barbachyn, Douglas K. Hutchinson, Steven J. Brickner et al. · Journal of Medicinal Chemistry · 1996 · 234 citations

Synthesis of a Series of Stromelysin-Selective Thiadiazole Urea Matrix Metalloproteinase Inhibitors

E. Jon Jacobsen, Mark A. Mitchell, Susan K. Hendges et al. · Journal of Medicinal Chemistry · 1999 · 57 citations · Full text

Medicinal Chemistry, Amino Acid Component, Bioorganic Chemistry +14

Synthetic matrix metalloproteinase inhibitors and tissue inhibitor of metalloproteinase (TIMP)-2, but not TIMP-1, inhibit shedding of tumor necrosis factor-alpha receptors in a human colon adenocarcinoma (Colo 205) cell line.

M A Lombard, T L Wallace, Marc F. Kubicek et al. · PubMed · 1998 · 56 citations

Colo 205, Immunology, Pathology +22

Synthesis and antibacterial activity of new tropone-substituted phenyloxazolidinone antibacterial agents 2. Modification of the phenyl ring — the potentiating effect of fluorine substitution on in vivo activity

Michael R. Barbachyn, Dana S. Toops, Kevin C. Grega et al. · Bioorganic & Medicinal Chemistry Letters · 1996 · 23 citations

Vivo Activity, Antimicrobial Drug Discovery, Fluorine Substitution +12