Inhibiting angiogenesis and tumorigenesis by a synthetic molecule that blocks binding of both VEGF and PDGF to their receptors

Jiazhi Sun, De-an Wang, Rishi K. Jain, +8

Oncogene

AngiogenesisMedicineSynthetic MoleculeCancer GrowthVascular Biology +6

A chemical biology approach identifies a beta-2 adrenergic receptor agonist that causes human tumor regression by blocking the Raf-1/Mek-1/Erk1/2 pathway

Adam Carie, Saı̈d M. Sebti

Oncogene

Molecular PharmacologyTumor BiologyMedicineReceptor Tyrosine KinaseChemical Biology Approach +8

Blockade of Protein Geranylgeranylation Inhibits Cdk2-Dependent p27^Kip1 Phosphorylation on Thr187 and Accumulates p27^Kip1 in the Nucleus: Implications for Breast Cancer Therapy

Aslamuzzaman Kazi, Adam Carie, Michelle A. Blaskovich, +10

Molecular and Cellular Biology

Nuclear P27Tumor BiologyLow Nuclear P27Signal TransductionSignaling Pathway +13

A Versatile Polymer Micelle Drug Delivery System for Encapsulation and <i>In Vivo</i> Stabilization of Hydrophobic Anticancer Drugs

Jonathan Rios‐Doria, Adam Carie, Tara Lee Costich, +4

Journal of Drug Delivery

NanoparticlesEngineeringResponsive PolymersBiomedical EngineeringNanomedicine +14

Structure–activity studies on a library of potent calix[4]arene-based PDGF antagonists that inhibit PDGF-stimulated PDGFR tyrosine phosphorylation

Huchen Zhou, De-an Wang, Laura Baldini, +4

Organic & Biomolecular Chemistry

A Small Molecule Disruptor of Rb/Raf-1 Interaction Inhibits Cell Proliferation, Angiogenesis, and Growth of Human Tumor Xenografts in Nude Mice

Rebecca Kinkade, Piyali Dasgupta, Adam Carie, +6

Cancer Research

Synthesis and Characterization of Micelle-Forming PEG-Poly(Amino Acid) Copolymers with Iron-Hydroxamate Cross-Linkable Blocks for Encapsulation and Release of Hydrophobic Drugs

Kevin Sill, Bradford Sullivan, Adam Carie, +1

Biomacromolecules

Ethylene GlycolEngineeringPeptide SciencePolymersNanomedicine +18

IT-141, a Polymer Micelle Encapsulating SN-38, Induces Tumor Regression in Multiple Colorectal Cancer Models

Adam Carie, Jonathan Rios‐Doria, Tara Lee Costich, +4

Journal of Drug Delivery

Polymer MicellesCancer BiologyTumor BiologyNanomedicineOncology +15

Development and <i>in Vivo</i> Quantitative Magnetic Resonance Imaging of Polymer Micelles Targeted to the Melanocortin 1 Receptor

Natalie M. Barkey, Christian Preihs, Heather H. Cornnell, +11

Journal of Medicinal Chemistry

EngineeringMagnetic ResonanceBiomedical EngineeringTumor BiologyNanomedicine +17

Imaging the delivery of drug-loaded, iron-stabilized micelles

Suzanne J. Bakewell, Adam Carie, Tara Lee Costich, +6

Nanomedicine Nanotechnology Biology and Medicine

NanoparticlesNanotherapeuticsEngineeringNanotechnology Drug DeliveryBiomedical Engineering +15