Saı̈d M. Sebti

Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity

Khandaker Siddiquee, Shumin Zhang, Wayne C. Guida et al. · Proceedings of the National Academy of Sciences · 2007 · 743 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +14

Discovery of JSI-124 (cucurbitacin I), a selective Janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells in mice.

Michelle A. Blaskovich, Jiazhi Sun, Alan Cantor et al. · PubMed · 2003 · 569 citations

Medicine, Oncology, Pharmacology +15

Akt/Protein Kinase B Signaling Inhibitor-2, a Selective Small Molecule Inhibitor of Akt Signaling with Antitumor Activity in Cancer Cells Overexpressing Akt

Lin Yang, Han C. Dan, Mei Sun et al. · Cancer Research · 2004 · 423 citations

Medicine, Oncology, Pharmacology +17

Ras CAAX Peptidomimetic FTI-277 Selectively Blocks Oncogenic Ras Signaling by Inducing Cytoplasmic Accumulation of Inactive Ras-Raf Complexes

Edwina C. Lerner, Yimin Qian, Michelle A. Blaskovich et al. · Journal of Biological Chemistry · 1995 · 360 citations · Full text

Life Sciences, Biochemistry, Pharmacology +17

Regulation of Dendritic Cell Differentiation and Antitumor Immune Response in Cancer by Pharmacologic-Selective Inhibition of the Janus-Activated Kinase 2/Signal Transducers and Activators of Transcription 3 Pathway

Yulia Nefedova, Srinivas Nagaraj, Amsler Rosenbauer et al. · Cancer Research · 2005 · 312 citations · Full text

Life Sciences, Immunology, Oncology +16