Intezyne (United States)

Safety and activity of IT-139, a ruthenium-based compound, in patients with advanced solid tumours: a first-in-human, open-label, dose-escalation phase I study with expansion cohort

Howard A. Burris, Suzanne J. Bakewell, Johanna C. Bendell et al. · ESMO Open · 2016 · 152 citations · Full text

Medicine, Oncology, Pharmacology +12

A Versatile Polymer Micelle Drug Delivery System for Encapsulation and <i>In Vivo</i> Stabilization of Hydrophobic Anticancer Drugs

Jonathan Rios‐Doria, Adam Carie, Tara Lee Costich et al. · Journal of Drug Delivery · 2012 · 52 citations · Full text

Pharmacy, Oncology, Pharmaceutics +17

Suppression of stress induction of the 78-kilodalton glucose regulated protein (GRP78) in cancer by IT-139, an anti-tumor ruthenium small molecule inhibitor

Suzanne J. Bakewell, Daisy F. Rangel, Dat P. Ha et al. · Oncotarget · 2018 · 49 citations · Full text

Medicine, Oncology, Pharmacology +15

Synthesis and Characterization of Micelle-Forming PEG-Poly(Amino Acid) Copolymers with Iron-Hydroxamate Cross-Linkable Blocks for Encapsulation and Release of Hydrophobic Drugs

Kevin Sill, Bradford Sullivan, Adam Carie et al. · Biomacromolecules · 2017 · 48 citations · Full text

Pharmacy, Pharmaceutics, Pharmacokinetics +17

Development of Melanoma-Targeted Polymer Micelles by Conjugation of a Melanocortin 1 Receptor (MC1R) Specific Ligand

Natalie M. Barkey, Narges K. Tafreshi, J.S. Josan et al. · Journal of Medicinal Chemistry · 2011 · 47 citations · Full text

Pharmacy, Medicinal Chemistry, Oncology +17