Proteotoxic Stress Induces Phosphorylation of p62/SQSTM1 by ULK1 to Regulate Selective Autophagic Clearance of Protein Aggregates

Junghyun Lim, M. Lenard Lachenmayer, Shuai Wu, +7

PLoS Genetics

ALS-FTLD-linked mutations of SQSTM1/p62 disrupt selective autophagy and NFE2L2/NRF2 anti-oxidative stress pathway

Zhiqiang Deng, Junghyun Lim, Qian Wang, +10

Autophagy

Autophagy Regulation of Metabolism Is Required for CD8+ T Cell Anti-tumor Immunity

Lindsay DeVorkin, Nils Pavey, Gillian Carleton, +18

Cell Reports

ULK1-mediated phosphorylation of ATG14 promotes autophagy and is impaired in Huntington’s disease models

Mitchell S. Wold, Junghyun Lim, Véronik Lachance, +2

Molecular Neurodegeneration

Selective autophagy of the adaptor TRIF regulates innate inflammatory signaling

Mohammad Samie, Junghyun Lim, Erik Verschueren, +11

Nature Immunology

InflammationCell AutophagySelective AutophagySignal TransductionInnate Immune System +8

Sequential application of plasma-activated water and mild heating improves microbiological quality of ready-to-use shredded salted kimchi cabbage (Brassica pekinensis L.)

Eun Ji Choi, Hae Woong Park, Sung Bong Kim, +5

Food Control

Microbial HazardEngineeringMicrobial ContaminationEnvironmental EngineeringFoodborne Pathogens +12

Autophagy regulates inflammatory programmed cell death via turnover of RHIM-domain proteins

Junghyun Lim, Hyunjoo Park, Jason Heisler, +7

eLife

MISTERMINATE Mechanistically Links Mitochondrial Dysfunction with Proteostasis Failure

Zhihao Wu, Ishaq Tantray, Junghyun Lim, +11

Molecular Cell

Mitochondrial FunctionPhysiologyMitochondrial MedicineProteostasis FailureMetabolism +3

Ubiquitination of ABCE1 by NOT4 in Response to Mitochondrial Damage Links Co-translational Quality Control to PINK1-Directed Mitophagy

Zhihao Wu, Yan Wang, Junghyun Lim, +6

Cell Metabolism

MitophagyProtein Quality ControlPink1-directed MitophagyMitochondrial FunctionMitochondrial Dynamic +7

Binding preference of p62 towards LC3-ll during dopaminergic neurotoxin-induced impairment of autophagic flux

Junghyun Lim, Hyun-Wook Kim, Moussa B. H. Youdim, +3

Autophagy

MitophagyAutophagic FluxCell DeathPrototypic Autophagic EventsCell Autophagy +17