Pharmacological dimerization and activation of the exchange factor eIF2B antagonizes the integrated stress response

Carmela Sidrauski, Jordan C. Tsai, Martin Kampmann, +14

eLife

Exchange Factor Eif2bMolecular BiologyCell CultureExperimental PharmacologyOxidative Stress +21

Affinity purification–mass spectrometry and network analysis to understand protein-protein interactions

John H. Morris, Giselle M. Knudsen, Erik Verschueren, +4

Nature Protocols

BiochemistryInteractomicsNatural SciencesAffinity Purification–mass SpectrometryMedicine +8

Global Mapping of Herpesvirus-Host Protein Complexes Reveals a Transcription Strategy for Late Genes

Zoe H. Davis, Erik Verschueren, Gwendolyn Μ. Jang, +13

Molecular Cell

Late GenesViral ReplicationFunctional GenomicsMolecular VirologyHerpesvirus-host Protein Complexes +10

OTULIN limits cell death and inflammation by deubiquitinating LUBAC

Klaus Heger, Katherine E. Wickliffe, Ada Ndoja, +19

Nature

InflammationApoptosisImmunologyOtulin LimitsCell Death +3

Global Mapping of the Inc-Human Interactome Reveals that Retromer Restricts Chlamydia Infection

Kathleen M. Mirrashidi, Cherilyn A. Elwell, Erik Verschueren, +20

Cell Host & Microbe

GeneticsPathogenesisGlobal MappingMedicineClinical Microbiology +2

The mTOR Complex Controls HIV Latency

Emilie Besnard, Shweta Hakre, Martin Kampmann, +16

Cell Host & Microbe

Sexual HealthHuman RetrovirusImmunologyAntiviral ResponseVirology +4

A Combined Proteomics/Genomics Approach Links Hepatitis C Virus Infection with Nonsense-Mediated mRNA Decay

Holly Ramage, G. Renuka Kumar, Erik Verschueren, +8

Molecular Cell

Viral ReplicationMolecular VirologyViral HepatitisNatural SciencesImmunology +9

Dynamic Regulation of Mitochondrial Import by the Ubiquitin System

Lilian Phu, Christopher M. Rose, Joy S. Tea, +5

Molecular Cell

Mitochondrial FunctionMitochondrial ImportMitochondrial DynamicCellular BiochemistryMetabolism +3

MassIVE.quant: a community resource of quantitative mass spectrometry–based proteomics datasets

Meena Choi, Jeremy Carver, Cristina Chiva, +20

Nature Methods

Proteomic TechnologyMedicineNatural SciencesOmics DatasetsMass Spectrometry +8

Selective autophagy of the adaptor TRIF regulates innate inflammatory signaling

Mohammad Samie, Junghyun Lim, Erik Verschueren, +11

Nature Immunology

InflammationCell AutophagySelective AutophagySignal TransductionInnate Immune System +8