Concepedia

ALS-FTLD-linked mutations of SQSTM1/p62 disrupt selective autophagy and NFE2L2/NRF2 anti-oxidative stress pathway

Zhiqiang Deng, Junghyun Lim, Qian Wang, Kerry Purtell, Shuai Wu, Gloria M. Palomo, Haiyan Tan, Giovanni Manfredi, Yanxiang Zhao, Junmin Peng,

Autophagy · 2019 · 219 citations · 47 references

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Abstract

ssociation; ULK1: unc-51 like autophagy activating kinase 1; WT: wild type.

References

47

limma powers differential expression analyses for RNA-sequencing and microarray studies

Matthew E. Ritchie, Belinda Phipson, Di Wu et al. · Nucleic Acids Research · 2015 · 43K citations · Full text

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Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

D.R. Rosen, Teepu Siddique, David T. Patterson et al. · Nature · 1993 · 7K citations

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The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1

Masaaki Komatsu, Satoshi Waguri, Keiko Taguchi et al. · Nature Cell Biology · 2010 · 2.4K citations

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Homeostatic Levels of p62 Control Cytoplasmic Inclusion Body Formation in Autophagy-Deficient Mice

Masaaki Komatsu, Satoshi Waguri, Masato Koike et al. · Cell · 2007 · 2.1K citations · Full text

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Phosphorylation of the Autophagy Receptor Optineurin Restricts <i>Salmonella</i> Growth

Philipp S. Wild, Hesso Farhan, David G. McEwan et al. · Science · 2011 · 1.3K citations

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