ULK1 Signaling is a molecular regulatory mechanism within autophagy pharmacology that initiates autophagosome formation through the activation and phosphorylation of downstream autophagy-related proteins in response to cellular energy and nutrient sensing pathways.
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AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
Joungmok Kim, Mondira Kundu, Benoı̂t Viollet et al. · Nature Cell Biology · 2011 · 7K citations · Full text
ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase
Ryan C. Russell, Ye Tian, Hai‐Xin Yuan et al. · Nature Cell Biology · 2013 · 1.5K citations · Full text
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