Robert C. Orchard

Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9

John G. Doench, Nicolò Fusi, Meagan E. Sullender et al. · Nature Biotechnology · 2016 · 4.7K citations · Full text

Systems Biology, Off-target Effect, Natural Sciences +10

RETRACTED ARTICLE: Molecular characterization of LC3-associated phagocytosis reveals distinct roles for Rubicon, NOX2 and autophagy proteins

Jennifer Martinez, R. K. Subbarao Malireddi, Qun Lu et al. · Nature Cell Biology · 2015 · 770 citations · Full text

Inflammation, Cell Autophagy, Molecular Characterization +9

Genome-wide CRISPR Screens Reveal Host Factors Critical for SARS-CoV-2 Infection

Jin Wei, Mia Madel Alfajaro, Peter C. DeWeirdt et al. · Cell · 2020 · 572 citations · Full text

Sars-cov-2 Infection, Pathogenesis, Virology +8

RETRACTED ARTICLE: Noncanonical autophagy inhibits the autoinflammatory, lupus-like response to dying cells

Jennifer Martinez, Larissa D. Cunha, Sunmin Park et al. · Nature · 2016 · 384 citations · Full text

Apoptosis, Immunology, Cell Death +19

Discovery of a proteinaceous cellular receptor for a norovirus

Robert C. Orchard, Craig B. Wilen, John G. Doench et al. · Science · 2016 · 288 citations · Full text