Rong‐Sheng Yang

Crystal Structures of MEK1 Binary and Ternary Complexes with Nucleotides and Inhibitors

Thierry Fischmann, Catherine K. Smith, Todd Mayhood et al. · Biochemistry · 2009 · 174 citations

Crystal Structure, Molecular Biology, Kinase Domain Spans +19

Discovery of the HCV NS3/4A Protease Inhibitor (1<i>R</i>,5<i>S</i>)-<i>N</i>-[3-Amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3- [2(<i>S</i>)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]- 6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2(<i>S</i>)-carboxamide (Sch 503034) II. Key Steps in Structure-Based Optimization

Andrew Prongay, Zhuyan Guo, Nanhua Yao et al. · Journal of Medicinal Chemistry · 2007 · 106 citations · Full text

Protein Assembly, Molecular Biology, Structure-based Optimization +22

Profiling Active Enzymes for Polysorbate Degradation in Biotherapeutics by Activity-Based Protein Profiling

Xuanwen Li, Divya Chandra, Simon Letarte et al. · Analytical Chemistry · 2021 · 60 citations

Engineering, Polysorbate Degradation, Enzyme Activity Information +19

Engineering Hydroxylase Activity, Selectivity, and Stability for a Scalable Concise Synthesis of a Key Intermediate to Belzutifan

Wai Ling Cheung‐Lee, Joshua N. Kolev, John A. McIntosh et al. · Angewandte Chemie International Edition · 2024 · 51 citations · Full text

Key Intermediate, Engineering, Enzyme Stability +16

Extensive Characterization of Polysorbate 80 Oxidative Degradation Under Stainless Steel Conditions

Xiwei Zheng, Adam T. Sutton, Rong‐Sheng Yang et al. · Journal of Pharmaceutical Sciences · 2022 · 25 citations

Advanced Oxidation Process, Chemical Engineering, Engineering +8