Joshua N. Kolev

Design of an in vitro biocatalytic cascade for the manufacture of islatravir

Mark A. Huffman, Anna Fryszkowska, Oscar Alvizo et al. · Science · 2019 · 631 citations

Engineering, Biotechnology, Pharmaceutical Biotechnology +17

Enzymatic C(sp³)-H Amination: P450-Catalyzed Conversion of Carbonazidates into Oxazolidinones

Ritesh Singh, Joshua N. Kolev, Philip Sutera et al. · ACS Catalysis · 2015 · 172 citations · Full text

Natural Sciences, Biochemistry, Chemistry +14

A kinase-cGAS cascade to synthesize a therapeutic STING activator

John A. McIntosh, Zhijian Liu, Brian M. Andresen et al. · Nature · 2022 · 135 citations

Life Sciences, Molecular Biology, Pharmacology +10

Discovery of Potent Parthenolide-Based Antileukemic Agents Enabled by Late-Stage P450-Mediated C—H Functionalization

Joshua N. Kolev, Kristen M. O’Dwyer, Craig T. Jordan et al. · ACS Chemical Biology · 2013 · 114 citations

Pharmacy, Medicinal Chemistry, Pharmacology +15

Enhancing the Efficiency and Regioselectivity of P450 Oxidation Catalysts by Unnatural Amino Acid Mutagenesis

Joshua N. Kolev, Jacqueline M. Zaengle, Rajesh Ravikumar et al. · ChemBioChem · 2014 · 84 citations

Life Sciences, Biochemistry, Biotechnology +17