Aaron M. Hosios

Supporting Aspartate Biosynthesis Is an Essential Function of Respiration in Proliferating Cells

Lucas B. Sullivan, Dan Y. Gui, Aaron M. Hosios et al. · Cell · 2015 · 1.1K citations · Full text

Cell Physiology, Reductive Stress, Essential Function +13

Amino Acids Rather than Glucose Account for the Majority of Cell Mass in Proliferating Mammalian Cells

Aaron M. Hosios, Vivian Hecht, Laura V. Danai et al. · Developmental Cell · 2016 · 636 citations · Full text

Energy Metabolism, Biochemistry, Cellular Nutrition +12

Tissue of origin dictates branched-chain amino acid metabolism in mutant<i>Kras</i>-driven cancers

Jared R. Mayers, Margaret E. Torrence, Laura V. Danai et al. · Science · 2016 · 559 citations · Full text

PKM2 Isoform-Specific Deletion Reveals a Differential Requirement for Pyruvate Kinase in Tumor Cells

William J. Israelsen, Talya L. Dayton, Shawn M. Davidson et al. · Cell · 2013 · 539 citations · Full text

Aspartate is an endogenous metabolic limitation for tumour growth

Lucas B. Sullivan, Alba Luengo, Laura V. Danai et al. · Nature Cell Biology · 2018 · 334 citations · Full text

Tumor Biology, Tumour Growth, Medicine +6